Big Mother or Small Baby: Which Predicts Hypertension?

被引:46
作者
Filler, Guido [1 ]
Yasin, Abeer [1 ]
Kesarwani, Priya [1 ]
Garg, Amit X. [2 ]
Lindsay, Robert [2 ]
Sharma, Ajay P. [1 ]
机构
[1] Univ Western Ontario, London Hlth Sci Ctr, Childrens Hosp, Dept Pediat,Div Pediat Nephrol, London, ON N6A 5W9, Canada
[2] Univ Western Ontario, Dept Med, Div Nephrol, Schulich Sch Med & Dent, London, ON N6A 5W9, Canada
关键词
LOW-BIRTH-WEIGHT; BLOOD-PRESSURE; DEVELOPMENTAL ORIGINS; CHILDHOOD GROWTH; BODY-COMPOSITION; KIDNEY-DISEASE; ADULT LIFE; FETAL; PATTERNS; CHILDREN;
D O I
10.1111/j.1751-7176.2010.00366.x
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
According to the Barker hypothesis, intrauterine growth restriction and premature delivery adversely affect cardiovascular health in adult life. The association of childhood hypertension as a cardiovascular risk factor and birth weight has been understudied. In a prospective cohort study, the authors evaluated the effect of birth weight, gestational age, maternal prepregnancy body mass index (BMI), and child BMI z score at the time of enrollment on the systolic and diastolic blood pressure (BP) z score in 3024 (1373 women) consecutive outpatient clinic patients aged 2.05 to 18.58 years. The latest National Health and Nutrition Examination Survey (NHANES III) was used to calculate the age-dependent z scores. The median z scores of BMI (+0.48, range -6.96-6.64), systolic BP (+0.41, range -4.50-6.73), and diastolic BP (+0.34, range -3.15-+6.73) were all significantly greater than the NHANES III reference population. Systolic BP z score did not correlate with birth weight or gestational age, but did correlate with maternal prepregnancy BMI (r=.090, P <.0001) and BMI z score (r=.209, P <.0001). Diastolic BP z score positively correlated with birth weight (0.037, P=.044), gestational age (r=.052, P=.005), BMI z score(r=.106, P <.0001), and maternal prepregnancy BMI (r=.062, P=.0007). In contrast to what would be expected from the Barker hypothesis, the authors found no negative correlation between BP z score and birth weight or gestational age. This study suggests that a high BMI, a big mom, and a high birth weight are more important risk factors for hypertension during childhood than low birth weight or gestational age. J Clin Hypertens (Greenwich). 2011;13:35-41. (c) 2010 Wiley Periodicals, Inc.
引用
收藏
页码:35 / 41
页数:7
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