Neutrophils, from Marrow to Microbes

被引：1068

作者：

Borregaard, Niels ^{[1
]}

机构：

[1] Univ Copenhagen, Rigshosp, Natl Univ Hosp, Granulocyte Res Lab,Dept Hematol, DK-2100 Copenhagen, Denmark

来源：

IMMUNITY | 2010年 / 33卷 / 05期

基金：

英国医学研究理事会;

关键词：

COLONY-STIMULATING FACTOR; BINDING-PROTEIN-EPSILON; JUNCTIONAL ADHESION MOLECULE; PEROXIDASE-NEGATIVE GRANULES; ACTIVATED ENDOTHELIAL-CELLS; HEMATOPOIETIC STEM-CELLS; LEUKOCYTE ADHESION; IN-VIVO; SUBCELLULAR-LOCALIZATION; BONE-MARROW;

D O I：

10.1016/j.immuni.2010.11.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules. These contain proteins that enable the neutrophil to deliver lethal hits against microorganisms, but also to cause great tissue damage. Neutrophils circulate in the blood as dormant cells. At sites of infection, endothelial cells capture bypassing neutrophils and guide them through the endothelial cell lining whereby the neutrophils are activated and tuned for the subsequent interaction with microbes. Once in tissues, neutrophils kill microorganisms by microbicidal agents liberated from granules or generated by metabolic activation. As a final act, neutrophils can extrude stands of DNA with bactericidal proteins attached that act as extracellular traps for microorganisms.

引用

页码：657 / 670

页数：14

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