A new link between pesticides and Parkinson's disease

被引:60
作者
Giasson, BI [1 ]
Lee, VMY [1 ]
机构
[1] Univ Penn, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA
关键词
D O I
10.1038/81737
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Environmental factors are thought to be an important cause od Parkinson's disease, a new study shows that rats chronically treated with the mitochondrial inhibitor rotenone, a common pesticide, develop neuropathological and behavioral symptoms sf Parkinsonism.
引用
收藏
页码:1227 / 1228
页数:2
相关论文
共 17 条
[1]   Mitochondria, free radicals, and neurodegeneration [J].
Beal, MF .
CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (05) :661-666
[2]   Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].
Betarbet, R ;
Sherer, TB ;
MacKenzie, G ;
Garcia-Osuna, M ;
Panov, AV ;
Greenamyre, JT .
NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306
[3]   Postencephalitic parkinsonism - a review [J].
Casals, J ;
Elizan, TS ;
Yahr, MD .
JOURNAL OF NEURAL TRANSMISSION, 1998, 105 (6-7) :645-676
[4]  
Duda JE, 2000, J NEUROSCI RES, V61, P121, DOI 10.1002/1097-4547(20000715)61:2<121::AID-JNR1>3.0.CO
[5]  
2-4
[6]   Prospects for new restorative and neuroprotective treatments in Parkinson's disease [J].
Dunnett, SB ;
Björklund, A .
NATURE, 1999, 399 (6738) :A32-A39
[7]   A Drosophila model of Parkinson's disease [J].
Feany, MB ;
Bender, WW .
NATURE, 2000, 404 (6776) :394-398
[8]  
Forno LS, 1996, ADV NEUROL, V69, P217
[9]   Neuropathology of Parkinson's disease [J].
Forno, LS .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (03) :259-272
[10]   Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions [J].
Giasson, BI ;
Duda, JE ;
Murray, IVJ ;
Chen, QP ;
Souza, JM ;
Hurtig, HI ;
Ischiropoulos, H ;
Trojanowski, JQ ;
Lee, VMY .
SCIENCE, 2000, 290 (5493) :985-989