Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells

被引：11

作者：

Park, J

Li, Q

Chang, YT

Kim, TS ^{[1
]}

机构：

[1] Chonnam Natl Univ, Coll Pharm, Dept Pharm, Kwangju 500757, South Korea

[2] Chonnam Natl Univ, Res Inst Drug Dev, Kwangju 500757, South Korea

[3] NYU, Dept Chem, New York, NY 10003 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 07期

关键词：

ceramide library; interleukin-4; T cells; allergy;

D O I：

10.1016/j.bmc.2005.01.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4(+) T cells, is an important stimulus for the switch of the antibody isotype to IgE in both mice and humans. In this study we investigated the inhibitory activity of IL-4 production in activated T cells by screening ceramide derivatives prepared by solid phase combinatorial chemistry. Many ceramide derivatives significantly inhibited IL-4 production in T cells. In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2589 / 2595

页数：7

共 44 条

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