Immune cell regulation of glia during CNS injury and disease

被引：299
作者：
Greenhalgh, Andrew D. [1 ]
David, Sam [2 ]
Bennett, F. Chris [3 ,4 ]
机构：
[1] Univ Bordeaux, INRA, Lab Nutr & Neurobiol Integree, Bordeaux, France
[2] McGill Univ, Hlth Ctr, Res Inst, Ctr Res Neurosci, Montreal, PQ, Canada
[3] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
[4] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2020年 / 21卷 / 03期
关键词：
CENTRAL-NERVOUS-SYSTEM; AMYOTROPHIC-LATERAL-SCLEROSIS; MONOCYTE-DERIVED MACROPHAGES; BRAINS CHOROID-PLEXUS; SPINAL-CORD-INJURY; CD4(+) T-CELLS; MOUSE MODEL; ALZHEIMERS-DISEASE; MYELOID CELL; IFN-GAMMA;
D O I：
10.1038/s41583-020-0263-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glial cells are abundant in the CNS and are essential for brain development and homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a possible contributing factor to neurodegenerative and psychiatric disease. Recent evidence suggests that microglia, which are also the brain's major resident immune cells, provide disease-modifying regulation of the other major glial populations, namely astrocytes and oligodendrocytes. In addition, peripheral immune cells entering the CNS after injury and in disease may directly affect microglial, astrocyte and oligodendrocyte function, suggesting an integrated network of immune cell-glial cell communication.
引用
收藏
页码：139 / 152
页数：14
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