A pilot study of blood lead levels and neurobehavioral function in children living in Chennai, India

被引：32

作者：

Bellinger, DC

Hu, H

Kalaniti, K

Thomas, N

Rajan, P

Sambandam, S

Ramaswamy, P

Balakrishnan, K

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Channing Lab, Boston, MA 02115 USA

[4] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[5] Sri Ramachandra Med Coll & Res Inst, Dept Environm Hlth & Engn, Madras, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH | 2005年 / 11卷 / 02期

关键词：

lead; neurobehavior; India;

D O I：

10.1179/oeh.2005.11.2.138

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The relationship between blood lead level and neurodevelopment was assessed in a pilot cross-sectional study of 74 4-14-year-old children in Chermai, India. Mean blood lead level was 11.1 mu g/dL (2.5-38.3). The Binet-Kamath IQ test and the Wide Range Assessment of Visual Motor Activity (WRAVMA) were administered to 58 children. Teachers completed the Connor ' s Behavioral Rating Scale. Excluding two outliers, IQ and WRAVMA composite scores were inversely related to blood lead level, with an effect size of approximately 6 points decline for a 10-mu g/dL increase in blood lead. Children in the highest and lowest blood lead quartiles had mean IQs of 95.6 +/- 13.3 and 102.0 +/- 22.5, respectively. Behavior ratings were not associated with blood lead level. Lead exposure is a significant problem among Indian children, with many having blood lead levels associated with increased neurodevelopmental risk.

引用

页码：138 / 143

页数：6

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