Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis

The development of efficient transgenic technologies in mice has allowed the study of the consequences of genetic alterations on cardiovascular (patho)physiology, although the development of such models have been hampered by size limitation of species resulting in time-consuming, labor-intensive and costly analyses. This overview summarizes the murine models currently available for studying or manipulating angiogenesis, arterial stenosis, atherosclerosis, transplant arteriopathy, thrombosis, thrombolysis and bleeding and addresses techniques to evaluate vascular development during embryogenesis. (C) 1998 Elsevier Science B.V. All rights reserved.