Bronsted acid promoted one-pot synthesis of 4-aryl-3,4-dihydrocoumarins

被引：5

作者：

Chen, Cheng ^{[2
]}

Zhang, Rui ^{[1
]}

Lin, Long ^{[1
]}

Yang, Guang-Fu ^{[1
]}

Wu, Qiong-You ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

[2] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China

来源：

TETRAHEDRON | 2016年 / 72卷 / 27-28期

基金：

中国国家自然科学基金;

关键词：

Dihydrocoumarins; Friedel-Crafts alkylation; Cycloaddition; Bronsted acid; Perchloric acid; MEDIATED HYDROARYLATION; MICROWAVE IRRADIATION; BENZYLIC ALCOHOLS; DIHYDROCOUMARINS; PHENOLS; COUMARINS; EFFICIENT; TANNINS; ARENES; DERIVATIVES;

D O I：

10.1016/j.tet.2016.05.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Aryl-3,4-dihydrocoumarins are a class of valuable molecules demonstrating attractive pharmaceutical and biological properties. In this paper, we designed a new and facile approach to synthesis of 4-aryl-3,4-dihydrocoumarin derivatives by Bronsted acid catalyzed Friedel Crafts alkylation and cycloaddition reaction. With this protocol, 15 examples of 4-aryl-3,4-dihydrocoumarins were successfully prepared with yields ranging from 82 to 99%. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3917 / 3921

页数：5

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