Effect of chromium supplementation on glucose metabolism and lipids - A systematic review of randomized controlled trials

被引:188
作者
Balk, Ethan M.
Tatsioni, Athina
Lichtenstein, Alice H.
Lau, Joseph
Pittas, Anastassios G.
机构
[1] Tufts Univ, New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA
[2] Tufts Univ, Clin Nutr Lab, Jean Mayer USDA Human Nutr, Res Ctr Aging, Boston, MA 02111 USA
[3] Tufts Univ, New England Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02111 USA
关键词
D O I
10.2337/dc06-0996
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - A systematic review of the effect of chromium supplementation on glucose metabolism and lipid levels. RESEARCH DESIGN AND METHODS - A literature search was conducted in MEDLINE and the Commonwealth Agricultural Bureau. Eligible studies were English language randomized controlled trials of chromium supplement intake >= 3 weeks, with >= 10 participants receiving chromium. All trials with glucose metabolism outcomes and trials of individuals with diabetes or glucose intolerance for lipid outcomes were included. Meta-analyses were performed as appropriate. RESULTS - Forty-one studies met criteria, almost half of which were of poor quality. Among participants with type 2 diabetes, chromium supplementation improved glycosylated hemoglobin levels by -0.6% (95% CI -0.9 to -0.2) and fasting glucose by -1.0 mmol/l (-1.4 to -0.5) but not lipids. There was no benefit in individuals without diabetes. There were some indications of dose effect and differences among chromium formulations. Larger effects were more commonly observed in poor-quality studies. The evidence was limited by poor study quality, heterogeneity in methodology and results, and a lack of consensus on assessment of chromium status. CONCLUSIONS - No significant effect of chromium on lipid or glucose metabolism was found in people without diabetes. Chromium supplementation significantly improved glycemia among patients with diabetes. However, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation.
引用
收藏
页码:2154 / 2163
页数:10
相关论文
共 60 条
[21]  
Genuth S, 2003, DIABETES CARE, V26, P3160
[22]   Role of chromium supplementation in Indians with type 2 diabetes mellitus [J].
Ghosh, D ;
Bhattacharya, B ;
Mukherjee, B ;
Manna, B ;
Sinha, M ;
Chowdhury, J ;
Chowdhury, S .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2002, 13 (11) :690-697
[23]   Tests of glycemia in diabetes [J].
Goldstein, DE ;
Little, RR ;
Lorenz, RA ;
Malone, JI ;
Nathan, D ;
Peterson, CM ;
Sacks, DB .
DIABETES CARE, 2004, 27 (07) :1761-1773
[24]  
GRANT AP, 1982, ULSTER MED J, V51, P110
[25]   Chromium and exercise training: Effect on obese women [J].
Grant, KE ;
Chandler, RM ;
Castle, AL ;
Ivy, JL .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1997, 29 (08) :992-998
[26]   Chromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile - A randomized, placebo-controlled, double-blind trial of supplementation in subjects with impaired glucose tolerance [J].
Gunton, JE ;
Cheung, NW ;
Hitchman, R ;
Hams, G ;
O'Sullivan, C ;
Foster-Powell, KE ;
McElduff, A .
DIABETES CARE, 2005, 28 (03) :712-713
[27]   EFFECTS OF CHROMIUM SUPPLEMENTATION ON PLASMA-LIPIDS, APOLIPOPROTEINS, AND GLUCOSE IN ELDERLY SUBJECTS [J].
HERMANN, J ;
ARQUITT, A ;
STOECKER, B .
NUTRITION RESEARCH, 1994, 14 (05) :671-674
[28]  
Hermann Janice, 1998, Journal of Nutrition for the Elderly, V18, P27, DOI 10.1300/J052v18n01_03
[29]   Trivalent chromium inhibits protein glycosylation and lipid peroxidation in high glucose-treated erythrocytes [J].
Jain, SK ;
Patel, P ;
Rogier, K ;
Jain, SK .
ANTIOXIDANTS & REDOX SIGNALING, 2006, 8 (1-2) :238-241
[30]   Chromium chloride inhibits TNFα and IL-6 secretion in isolated human blood mononuclear cells exposed to high glucose [J].
Jain, SK ;
Lim, G .
HORMONE AND METABOLIC RESEARCH, 2006, 38 (01) :60-62