Cardiac arrhythmias and rhabdomyolysis in Bartter-Gitelman patients

被引：15

作者：

Cortesi, Cinzia ^{[2
]}

Lava, Sebastiano A. G. ^{[2
]}

Bettinelli, Alberto ^{[3
]}

Tammaro, Fabiana ^{[3
]}

Giannini, Olivier ^{[4
]}

Caiata-Zufferey, Maria ^{[5
]}

Bianchetti, Mario G. ^{[1
,2
]}

机构：

[1] San Giovanni Hosp, CH-6500 Bellinzona, Switzerland

[2] Univ Bern, Mendrisio & Bellinzona Hosp, Dept Pediat, Bern, Switzerland

[3] San Leopoldo Mandic Hosp, Dept Pediat, Merate, Italy

[4] Osped Reg Beata Vergine, Mendrisio, Switzerland

[5] Univ Svizzera Italiana, Inst Commun & Hlth, Lugano, Switzerland

来源：

PEDIATRIC NEPHROLOGY | 2010年 / 25卷 / 10期

关键词：

Bartter syndrome; Cardiac arrhythmia; Gitelman syndrome; Hypokalemia; Hypomagnesemia; Rhabdomyolysis; Sudden cardiac death; LONG QT SYNDROME; SUDDEN-DEATH; HYPOKALEMIA; DISORDERS;

D O I：

10.1007/s00467-010-1580-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Recent data demonstrate that patients affected with hypokalemic salt-losing tubulopathies are prone to acute cardiac arrhythmias and rhabdomyolysis. The tendency to these potentially fatal complications is especially high if chronic hypokalemia is severe, in patients with diarrhea, vomiting or a prolonged QT interval on standard electrocardiography, in patients on drug management with compounds prolonging the electrocardiographic QT interval (including antiarrhythmic agents, some antihistamines, macrolides, antifungals, psychotropics, (2)-adrenergic agonists or cisapride), following acute alcohol abuse and during exercise. Cardiac arrhythmias and rhabdomyolysis occur with sufficient frequency in hypokalemic salt-losing tubulopathies to merit wider awareness of their presence and the preparation of specific prevention and management recommendations.

引用

页码：2005 / 2008

页数：4

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