Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

被引：58

作者：

Zhang, Xiaofei ^{[1
]}

Bertaso, Federica ^{[1
]}

Yoo, Jong W. ^{[2
]}

Baumgaertel, Karsten ^{[1
]}

Clancy, Sinead M. ^{[1
]}

Lee, Van ^{[3
]}

Cienfuegos, Cynthia ^{[3
]}

Wilmot, Carly ^{[3
]}

Avis, Jacqueline ^{[3
]}

Hunyh, Truc ^{[3
]}

Daguia, Catherine ^{[3
]}

Schmedt, Christian ^{[3
]}

Noebels, Jeffrey ^{[2
]}

Jegla, Timothy ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[3] Novartis Res Fdn, Genom Inst, San Diego, CA USA

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 09期

关键词：

K+ CHANNEL; BRAIN; BEHAVIOR; GENOME; GENES;

D O I：

10.1038/nn.2610

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found the voltage-gated K(+) channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2(-/-) (also known as Kcnh3(-/-)) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.

引用

页码：1056 / 1058

页数：3

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