Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study

被引：158

作者：

Ambatipudi, Srikant ^{[1
]}

Cuenin, Cyrille ^{[1
]}

Hernandez-Vargas, Hector ^{[1
]}

Ghantous, Akram ^{[1
]}

Le Calvez-Kelm, Florence ^{[1
]}

Kaaks, Rudolf ^{[2
]}

Barrdahl, Myrto ^{[2
]}

Boeing, Heiner ^{[3
]}

Aleksandrova, Krasimira ^{[3
]}

Trichopoulou, Antonia ^{[4
,5
]}

Lagiou, Pagona ^{[4
,5
]}

Naska, Androniki ^{[4
,5
]}

Palli, Domenico ^{[6
]}

Krogh, Vittorio ^{[7
]}

Polidoro, Silvia ^{[8
]}

Tumino, Rosario ^{[9
]}

Panico, Salvatore ^{[10
]}

Bueno-de-Mesquita, Bas ^{[11
,12
,13
,14
]}

Peeters, Petra H. M. ^{[15
,16
]}

Quiros, Jose Ramon ^{[17
]}

Navarro, Carmen ^{[18
,19
,20
]}

Ardanaz, Eva ^{[19
,21
,22
]}

Dorronsoro, Miren ^{[23
]}

Key, Tim ^{[24
]}

Vineis, Paolo ^{[25
]}

Murphy, Neil ^{[25
]}

Riboli, Elio ^{[25
]}

Romieu, Isabelle ^{[1
]}

Herceg, Zdenko ^{[1
]}

机构：

[1] IARC, Lyon, France

[2] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[3] German Inst Human Nutr Potsdam Rehbrcuke, Dept Epidemiol, Nuthetal, Germany

[4] Hellen Hlth Fdn, Athens, Greece

[5] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Nutr & Hlth,Unit Nutr Epide, GR-11527 Athens, Greece

[6] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[7] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[8] Human Genet Fdn HuGeF, Turin, Italy

[9] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, Rome, Italy

[10] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[11] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[12] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[13] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[14] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[15] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[16] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England

[17] Publ Hlth Directorate, Asturias, Spain

[18] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[19] CIBERESP, Murcia, Spain

[20] Univ Murcia, Dept Hlth & Social Sci, E-30001 Murcia, Spain

[21] Publ Hlth Inst Navarra, Pamplona, Spain

[22] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[23] Basque Reg Hlth Dept, Publ Hlth Direct & Biodonostia Ciberesp, San Sebastian, Spain

[24] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[25] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

来源：

EPIGENOMICS | 2016年 / 8卷 / 05期

关键词：

DNA methylome; epigenetic signature; prospective cohort; tobacco smoking; CIGARETTE-SMOKING; MATERNAL SMOKING; CANCER; DISCOVERY; MICROARRAY; NUTRITION; BETA; REPLICATION; ENVIRONMENT; VARIABILITY;

D O I：

10.2217/epi-2016-0001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. Materials & methods: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. Results: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. Conclusion: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.

引用

页码：599 / 618

页数：20

共 50 条

[31] Establishing an analytic pipeline for genome-wide DNA methylation
Wright, Michelle L.
Dozmorov, Mikhail G.
Wolen, Aaron R.
Jackson-Cook, Colleen
Starkweather, Angela R.
Lyon, Debra E.
York, Timothy P.
CLINICAL EPIGENETICS, 2016, 8
[32] DNA Hydroxymethylation in Smoking-Associated Cancers
Besaratinia, Ahmad
Caceres, Amanda
Tommasi, Stella
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (05)
[33] Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking
Ying Mao
Peng Huang
Yan Wang
Maiqiu Wang
Ming D. Li
Zhongli Yang
Clinical Epigenetics, 2021, 13
[34] Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis
Montalvo-Ortiz, Janitza L.
Zhang, Huiping
Chen, Chao
Liu, Chunyu
Coccaro, Emil F.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2018, 21 (01) : 12 - 20
[35] Genome-wide Analysis of DNA Methylation and Gene Expression Changes in the Mouse Lung following Subchronic Arsenate Exposure
Boellmann, Frank
Zhang, Lu
Clewell, Harvey J.
Schroth, Gary P.
Kenyon, Elaina M.
Andersen, Melvin E.
Thomas, Russell S.
TOXICOLOGICAL SCIENCES, 2010, 117 (02) : 404 - 417
[36] Comparison of genome-wide analysis techniques to DNA methylation analysis in human cancer
Soozangar, Narges
Sadeghi, Mohammad R.
Jeddi, Farhad
Somi, Mohammad H.
Shirmohamadi, Masoud
Samadi, Nasser
JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (05) : 3968 - 3981
[37] Landscape of genome-wide age-related DNA methylation in breast tissue
Song, Min-Ae
Brasky, Theodore M.
Weng, Daniel Y.
McElroy, Joseph P.
Marian, Catalin
Higgins, Michael J.
Ambrosone, Christine
Spear, Scott L.
Llanos, Adana A.
Kallakury, Bhaskar V. S.
Freudenheim, Jo L.
Shields, Peter G.
ONCOTARGET, 2017, 8 (70) : 114648 - 114662
[38] Dynamic changes in DNA methylation patterns in canine lymphoma cell lines demonstrated by genome-wide quantitative DNA methylation analysis
Yamazaki, J.
Jelinek, J.
Hisamoto, S.
Tsukamoto, A.
Inaba, M.
VETERINARY JOURNAL, 2018, 231 : 48 - 54
[39] The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells
Kanherkar, Riya R.
Getachew, Bruk
Ben-Sheetrit, Joseph
Varma, Sudhir
Heinbockel, Thomas
Tizabi, Yousef
Csoka, Antonei B.
INTERNATIONAL JOURNAL OF GENOMICS, 2018, 2018
[40] Genome-wide DNA Methylation Profiling of CpG Islands in Hypospadias
Choudhry, Shweta
Deshpande, Archana
Qiao, Liang
Beckman, Kenneth
Sen, Saunak
Baskin, Laurence S.
JOURNAL OF UROLOGY, 2012, 188 (04) : 1450 - 1455

← 1 2 3 4 5 →