Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study

被引：158

作者：

Ambatipudi, Srikant ^{[1
]}

Cuenin, Cyrille ^{[1
]}

Hernandez-Vargas, Hector ^{[1
]}

Ghantous, Akram ^{[1
]}

Le Calvez-Kelm, Florence ^{[1
]}

Kaaks, Rudolf ^{[2
]}

Barrdahl, Myrto ^{[2
]}

Boeing, Heiner ^{[3
]}

Aleksandrova, Krasimira ^{[3
]}

Trichopoulou, Antonia ^{[4
,5
]}

Lagiou, Pagona ^{[4
,5
]}

Naska, Androniki ^{[4
,5
]}

Palli, Domenico ^{[6
]}

Krogh, Vittorio ^{[7
]}

Polidoro, Silvia ^{[8
]}

Tumino, Rosario ^{[9
]}

Panico, Salvatore ^{[10
]}

Bueno-de-Mesquita, Bas ^{[11
,12
,13
,14
]}

Peeters, Petra H. M. ^{[15
,16
]}

Quiros, Jose Ramon ^{[17
]}

Navarro, Carmen ^{[18
,19
,20
]}

Ardanaz, Eva ^{[19
,21
,22
]}

Dorronsoro, Miren ^{[23
]}

Key, Tim ^{[24
]}

Vineis, Paolo ^{[25
]}

Murphy, Neil ^{[25
]}

Riboli, Elio ^{[25
]}

Romieu, Isabelle ^{[1
]}

Herceg, Zdenko ^{[1
]}

机构：

[1] IARC, Lyon, France

[2] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[3] German Inst Human Nutr Potsdam Rehbrcuke, Dept Epidemiol, Nuthetal, Germany

[4] Hellen Hlth Fdn, Athens, Greece

[5] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Nutr & Hlth,Unit Nutr Epide, GR-11527 Athens, Greece

[6] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[7] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[8] Human Genet Fdn HuGeF, Turin, Italy

[9] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, Rome, Italy

[10] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[11] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[12] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[13] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[14] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[15] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[16] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England

[17] Publ Hlth Directorate, Asturias, Spain

[18] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[19] CIBERESP, Murcia, Spain

[20] Univ Murcia, Dept Hlth & Social Sci, E-30001 Murcia, Spain

[21] Publ Hlth Inst Navarra, Pamplona, Spain

[22] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[23] Basque Reg Hlth Dept, Publ Hlth Direct & Biodonostia Ciberesp, San Sebastian, Spain

[24] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[25] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

来源：

EPIGENOMICS | 2016年 / 8卷 / 05期

关键词：

DNA methylome; epigenetic signature; prospective cohort; tobacco smoking; CIGARETTE-SMOKING; MATERNAL SMOKING; CANCER; DISCOVERY; MICROARRAY; NUTRITION; BETA; REPLICATION; ENVIRONMENT; VARIABILITY;

D O I：

10.2217/epi-2016-0001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. Materials & methods: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. Results: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. Conclusion: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.

引用

页码：599 / 618

页数：20

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