Pseudo-Polyrotaxane Stereocomplex with α-Cyclodextrin and Block Copolymers Using Poly(ethylene glycol) and Polylactide

被引：18

作者：

Choi, JaeYeong ^{[1
]}

Takata, Toshikazu ^{[2
,3
]}

Ajiro, Hiroharu ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Ikoma, Nara 6300192, Japan

[2] Tokyo Inst Technol, Sch Chem Sci & Engn, Yokohama, Kanagawa 2268503, Japan

[3] Hiroshima Univ, Grad Sch Adv Sci & Engn, Higashihiroshima, Hiroshima 7398527, Japan

来源：

MACROMOLECULES | 2021年 / 54卷 / 11期

关键词：

TRIBLOCK COPOLYMERS; POLYPSEUDOROTAXANES; DELIVERY; PLA;

D O I：

10.1021/acs.macromol.1c00220

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Three types of polylactide (PLA)-poly(ethylene glycol) (PEG) block copolymers (BCPs) were synthesized as ABA, AB, and BA types. We focused on different BCP structures, which might influence the rotaxane structure, to determine which part in BCP, PLA, or PEG, contributes to the penetration and stabilization of alpha-cyclodextrin (alpha-CD) as a ring moiety. Anionic ring-opening polymerization was used for the formation of the same length of PEG and PLA in the BCPs. The PLA-PEG pseudo-polyrotaxanes (PLA-PEG PPRXs) were then prepared using these PLA-PEG BCPs with alpha-CD. Herein, we detected that the alpha-CD existed near the PEG moiety in BCP, and this resulted in stereocomplex formation with the PLA moiety even after PPRXs were formed. This study also provides new information on the method of forming the PLA SC with PPRX, as well as the preparation of PLA-PPRXs using PLA-BCP and alpha-CD components.

引用

页码：5087 / 5093

页数：7

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