Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis and myelitis in COVID-19: a case report and a review of the literature

被引：9

作者：

Colantonio, Mark A. ^{[1
]}

Nwafor, Divine C. ^{[1
]}

Jaiswal, Shruti ^{[5
]}

Shrestha, Ashish K. ^{[2
]}

Elkhooly, Mahmoud ^{[3
]}

Rollins, Steven ^{[4
]}

Wen, Sijin ^{[4
]}

Sriwastava, Shitiz ^{[1
,6
]}

机构：

[1] West Virginia Univ, Sch Med, Morgantown, WV 26506 USA

[2] Kathmandu Med Coll, Teaching Hosp, Kathmandu, Nepal

[3] Minia Univ, Dept Neuropsychiat, Al Minya, Egypt

[4] West Virginia Univ, Dept Biostat, Morgantown, WV 26506 USA

[5] West Virginia Clin & Translat Sci Inst, Morgantown, WV USA

[6] West Virginia Univ, Rockefeller Neurosci Inst, Dept Neurol, 1 Med Ctr Dr,Suite 1310, Morgantown, WV 26506 USA

来源：

EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY | 2022年 / 58卷 / 01期

关键词：

COVID-19; SARS-CoV-2; MOG; Optic neuritis; Myelitis; CSF; MRI in COVID-19; CLINICAL SPECTRUM; ADULTS;

D O I：

10.1186/s41983-022-00496-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background Our case explored the spectrum of autoimmune and infectious neurological complications of Coronavirus Disease 2019. In addition, we also reviewed and discussed clinical features, neuroimaging, CSF findings, and outcomes in patients with COVID-19-associated Myelin Oligodendrocyte Glycoprotein Antibody Disorder (MOGAD) CNS inflammatory disorder. Case presentation Here we presented a case of post-Coronavirus Disease 2019 infection Myelin Oligodendrocyte Glycoprotein Antibody Disorder in a 41-year-old male who presented with gait instability, urinary retention, and confusion. Workup done in hospital showed transverse myelitis in cervical spine region and left optic neuritis. Laboratory findings showed Myelin Oligodendrocyte Glycoprotein-IgG antibodies were positive in serum (1:100), suggestive of post-COVID Myelin Oligodendrocyte Glycoprotein Antibody Disorder. Conclusion To our knowledge, this is the first comprehensive case report and the literature review that includes the clinical features, neuroimaging, CSF findings, and outcomes in COVID-19-associated Myelin Oligodendrocyte Glycoprotein Antibody Disorder.

引用

页数：12

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