DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group

被引：28

作者：

Kobayashi, T

Okuno, T

Suzuki, T

Kunita, M

Ohba, S

Nishida, Y ^{[1
]}

机构：

[1] Yamagata Univ, Fac Sci, Dept Chem, Yamagata 990, Japan

[2] Keio Univ, Fac Sci & Technol, Yokohama, Kanagawa 223, Japan

来源：

POLYHEDRON | 1998年 / 17卷 / 09期

关键词：

DNA cleavage; copper(II) and hydrogen peroxide; tripodal-ligands containing peptide group; supercoiled DNA;

D O I：

10.1016/S0277-5387(97)00368-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)(+) and Cu(dpgt)Cl+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)Cl+ and Cu(dpg)(+) complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1553 / 1559

页数：7