Role of Citrate in Pathophysiology and Medical Management of Bone Diseases

被引：67

作者：

Granchi, Donatella ^{[1
]}

Baldini, Nicola ^{[1
,2
]}

Ulivieri, Fabio Massimo ^{[3
]}

Caudarella, Renata ^{[4
]}

机构：

[1] IRCCS Ist Ortoped Rizzoli, Lab Orthoped Pathophysiol & Regenerat Med, Via Barbiano 1-10, I-40136 Bologna, Italy

[2] Univ Bologna, Dept Biomed & Neuromotor Sci, Via Pupilli 1, I-40136 Bologna, Italy

[3] IRCCS Ca Granda Osped Maggiore Policlin, Bone Metab Unit, Nucl Med, Via F Sforza 35, I-20122 Milan, Italy

[4] Maria Cecilia Hosp, GVM Care & Res, Via Corriera 1, I-48033 Cotignola, RA, Italy

来源：

NUTRIENTS | 2019年 / 11卷 / 11期

关键词：

bone metabolism; bone mineral density; bone remodelling; citrate supplement; osteopenia; osteoporosis; kidney diseases; AMORPHOUS CALCIUM-PHOSPHATE; ACID-BASE STATUS; POTASSIUM CITRATE; CITRIC-ACID; URINARY CITRATE; POSTMENOPAUSAL WOMEN; MITOCHONDRIAL ACONITASE; OSTEOPOROTIC FRACTURE; APATITE NANOCRYSTALS; PARATHYROID-HORMONE;

D O I：

10.3390/nu11112576

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Citrate is an intermediate in the "Tricarboxylic Acid Cycle" and is used by all aerobic organisms to produce usable chemical energy. It is a derivative of citric acid, a weak organic acid which can be introduced with diet since it naturally exists in a variety of fruits and vegetables, and can be consumed as a dietary supplement. The close association between this compound and bone was pointed out for the first time by Dickens in 1941, who showed that approximately 90% of the citrate bulk of the human body resides in mineralised tissues. Since then, the number of published articles has increased exponentially, and considerable progress in understanding how citrate is involved in bone metabolism has been made. This review summarises current knowledge regarding the role of citrate in the pathophysiology and medical management of bone disorders.

引用

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