Reactive carbonyls and oxidative stress: Potential for therapeutic intervention

被引：202

作者：

Ellis, Elizabeth M. ^{[1
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G1 1XW, Lanark, Scotland

来源：

PHARMACOLOGY & THERAPEUTICS | 2007年 / 115卷 / 01期

关键词：

aldehyde metabolism; oxidative stress; chemoprotection;

D O I：

10.1016/j.pharmthera.2007.03.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Reactive aldehydes and ketones are produced as a result of oxidative stress in several disease processes. Considerable evidence is now accumulating that these reactive carbonyl products are also involved in the progression of diseases, including neurodegenerative disorders, diabetes, atherosclerosis, diabetic complications, reperfusion after ischemic injury, hypertension, and inflammation. To counter carbonyl stress, cells possess enzymes that can decrease aldehyde load. These enzymes include aldehyde dehydrogenases (ALDH), aldo-keto reductases (AKR), carbonyl reductase (CBR), and glutathione S-transferases (GST). Some of these enzymes are inducible by chemoprotective compounds via Nrf2/ ARE- or AhR/XRE-dependent mechanisms. This review describes the metabolism of reactive carbonyls and discusses the potential for manipulatung levels of carbonyl-metabolizing enzymes through chemical intervention. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：13 / 24

页数：12

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