Prognostic significance of T cells, PD-L1 immune checkpoint and tumour associated macrophages in clear cell carcinoma of the ovary

被引：15

作者：

Sue-A-Quan, Rachel ^{[1
,2
]}

Patel, Palak G. ^{[2
,3
,4
]}

Shakfa, Noor ^{[1
,2
]}

Nyi, May-Phyo Nyi ^{[4
]}

Afriyie-Asante, Afrakoma ^{[1
,2
]}

Kang, Eun Young ^{[5
]}

Kobel, Martin ^{[5
]}

Koti, Madhuri ^{[1
,2
,6
]}

机构：

[1] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada

[2] Queens Univ, Queens Canc Res Inst, Canc Biol & Genet, Kingston, ON, Canada

[3] Hosp Sick Children, Dept Cell Biol, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada

[4] Queens Univ, Dept Pathol & Mol Med, Kingston, ON, Canada

[5] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB, Canada

[6] Queens Univ, Kingston Hlth Sci Ctr, Dept Obstet & Gynecol, Kingston, ON, Canada

来源：

GYNECOLOGIC ONCOLOGY | 2021年 / 162卷 / 02期

关键词：

RESISTANCE; ACTIVATION;

D O I：

10.1016/j.ygyno.2021.05.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. To define the pre-treatment tumour immune landscape of clear cell carcinoma of the ovary (CCOC). Methods. We investigated the infiltration profiles of selected immune cell populations and immune checkpoint proteins that have been previously shown to have prognostic relevance in high grade serous carcinoma of the ovary to determine their association with clinical outcomes in CCOC patients. Using multiplex immunohistochemistry, we evaluated the density of CD3+, FoxP3+, CD8+ T cells, CD20+ B cells and expression of PD-1, PD-L1 and IDO1 immune checkpoints in a cohort of 162 CCOC tumour specimens on a tissue microarray. Results. Increased infiltration of CD3+ CD8-(helper T) cells, CD8+ (cytotoxic T) cells, and CD68+ macrophages significantly associated with shorter disease-free survival, recurrence-free survival and overall survival. Importantly, higher expression of PD-L1 and IDO-1 immune checkpoints was associated with better clinical outcomes. Conclusion. Findings from our study are foundational towards the development of immune classifiers and biomarkers of response to immune checkpoint blockade therapy in CCOC. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：421 / 430

页数：10

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