RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner

被引：113
作者：
Mei, Lin [1 ]
Shen, Cheng [1 ]
Miao, Ran [2 ]
Wang, Jing-Zi [3 ]
Cao, Mend-Da [3 ]
Zhang, Yi-Sheng [1 ]
Shi, Liang-Hui [1 ]
Zhao, Guo-Hai [1 ]
Wang, Ming-Hai [1 ]
Wu, Li-Sheng [2 ]
Wei, Ji-Fu [3 ]
机构：
[1] Wannan Med Coll, Dept Gen Surg, Affiliated Yijishan Hosp 1, Wuhu 241001, Peoples R China
[2] Univ Sci & Technol China, Dept Gen Surg, Affiliated Hosp 1, Hefei 230001, Peoples R China
[3] Nanjing Med Univ, Res Div Clin Pharmacol, Affiliated Hosp 1, 300 Guangzhou Rd, Guangzhou 210029, Peoples R China
来源：
CELL DEATH & DISEASE | 2020年 / 11卷 / 04期
基金：
美国国家科学基金会;
关键词：
MESSENGER-RNA; EXPRESSION; DIFFERENTIATION; TRANSLATION; METHYLATION; PROGRESSION;
D O I：
10.1038/s41419-020-2487-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The RNA methyltransferase NSUN2 has been involved in the cell proliferation and senescence, and is upregulated in various types of cancers. However, the role and potential mechanism of NSUN2 in gastric cancer remains to be determined. Our study showed that NSUN2 was significantly upregulated in gastric cancers, compared to adjacent normal gastric tissues. Moreover, NSUN2 could promote gastric cancer cell proliferation both in vitro and in vivo. Further study demonstrated that CDKN1C (p57(Kip2)) was the potential downstream gene of regulated by NSUN2 in gastric cancer. NSUN2 could promote gastric cancer cell proliferation through repressing p57(Kip2) in an m(5)C-dependent manner. Our findings suggested that NSUN2 acted as an oncogene through promoting gastric cancer development by repressing p57(Kip2) in an m(5)C-dependent manner, which may provide a novel therapeutic target against gastric cancer.
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页数：11
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