c-Met: A Promising Therapeutic Target in Bladder Cancer

被引：16
作者：
Feng, Yanfei [1 ]
Yang, Zitong [2 ]
Xu, Xin [2 ,3 ]
机构：
[1] Zhejiang Chinese Med Univ, Affiliated Coll 2, Hangzhou, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Urol, Hangzhou, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Urol, 79th Qingchun Rd, Hangzhou 310003, Peoples R China
来源：
CANCER MANAGEMENT AND RESEARCH | 2022年 / 14卷
基金：
中国国家自然科学基金;
关键词：
c; -Met; HGF; noncoding RNA; bladder cancer; review; HEPATOCYTE GROWTH-FACTOR; RECEPTOR TYROSINE KINASE; TRANSITIONAL-CELL CARCINOMA; UROTHELIAL CARCINOMA; URINARY-BLADDER; SCATTER FACTOR; PROGNOSTIC INDICATOR; LUNG ADENOCARCINOMA; EXPRESSION; MIGRATION;
D O I：
10.2147/CMAR.S369175
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mesenchymal-epithelial transition factor (c-Met) belongs to the tyrosine kinase receptor family and is overexpressed in various human cancers. Its ligand is hepatocyte growth factor (HGF), and the HGF/c-Met signaling pathway is involved in a wide range of cellular processes, including cell proliferation, migration, and metastasis. Emerging studies have indicated that c-Met expression is strongly associated with bladder cancer (BCa) development and prognosis. Therefore, c-Met is a potential therapeutic target for BCa treatment. Recently, the aberrant expression of noncoding RNAs was found to play a significant role in tumour progression. There is a close connection between c-Met and noncoding RNA. Herein, we summarized the biological function and prognostic value of c-Met in BCa, as well as its potential role as a drug target. The relation of c-Met and ncRNA was also described in the paper.
引用
收藏
页码：2379 / 2388
页数：10
相关论文
共 79 条
[51]   Endoplasmic Reticulum Stress and Tumor Microenvironment in Bladder Cancer: The Missing Link [J].
Nie, Zhenyu ;
Chen, Mei ;
Wen, Xiaohong ;
Gao, Yuanhui ;
Huang, Denggao ;
Cao, Hui ;
Peng, Yanling ;
Guo, Na ;
Ni, Jie ;
Zhang, Shufang .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[52]  
Organ Shawna Leslie, 2011, Ther Adv Med Oncol, V3, pS7, DOI 10.1177/1758834011422556
[53]  
Parr C, 2001, INT J ONCOL, V19, P857
[54]   C-MET inhibitors for advanced non-small cell lung cancer [J].
Pasquini, Giulia ;
Giaccone, Giuseppe .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2018, 27 (04) :363-375
[55]   Increased miR-323a induces bladder cancer cell apoptosis by suppressing c-Met [J].
Qiu, Jun ;
Zeng, Fu-Ren ;
Fang, Yi ;
Li, Jian ;
Xiao, Sheng-Ying .
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2019, 35 (09) :542-549
[56]   Urinary and tissue levels of scatter factor in transitional cell carcinoma of bladder [J].
Rosen, EM ;
Joseph, A ;
Jin, L ;
Yao, Y ;
Chau, MHT ;
Fuchs, A ;
Gomella, L ;
Hastings, H ;
Goldberg, ID ;
Weiss, GH .
JOURNAL OF UROLOGY, 1997, 157 (01) :72-78
[57]   Profiling bladder cancer using targeted antibody arrays [J].
Sanchez-Carbayo, M ;
Socci, ND ;
Lozano, JJ ;
Haab, BB ;
Cordon-Cardo, C .
AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (01) :93-103
[58]   Expression of Axl in lung adenocarcinoma and correlation with tumor progression [J].
Shieh, YS ;
Lai, CY ;
Kao, YR ;
Shiah, SG ;
Chu, YW ;
Lee, HS ;
Wu, CW .
NEOPLASIA, 2005, 7 (12) :1058-1064
[59]   The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells [J].
Shintani, Terumichi ;
Kusuhara, Yoshito ;
Daizumoto, Kei ;
Dondoo, Tsogt-Ochir ;
Yamamoto, Hiroki ;
Mori, Hidehisa ;
Fukawa, Tomoya ;
Nakatsuji, Hiroyoshi ;
Fukumori, Tomoharu ;
Takahashi, Masayuki ;
Kanayama, Hiroomi .
UROLOGY, 2017, 101 :169.e7-169.e13
[60]   c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression [J].
Sim, Wen Jing ;
Iyengar, Prasanna Vasudevan ;
Lama, Dilraj ;
Lui, Sarah Kit Leng ;
Ng, Hsien Chun ;
Haviv-Shapira, Lior ;
Domany, Eytan ;
Kappei, Dennis ;
Tan, Tuan Zea ;
Saie, Azad ;
Jaynes, Patrick William ;
Verma, Chandra Shekhar ;
Kumar, Alan Prem ;
Rouanne, Mathieu ;
Ha, Hong Koo ;
Radulescu, Camelia ;
ten Dijke, Peter ;
Eichhorn, Pieter Johan Adam ;
Thiery, Jean Paul .
NATURE COMMUNICATIONS, 2019, 10 (1)
12345678