Behavioral, clinical and antinociceptive effects promoted by pre-emptive epidural injection of morphine, xylazine or clonidine, in horses

被引：0

作者：

Bueno do Prado Guirro, Erica Cristina ^{[1
]}

Sobrinho, Guilherme Roberto ^{[2
]}

Marchesini Ferreira, Isabella Maria ^{[3
]}

Araujo Valadao, Carlos Augusto ^{[4
]}

机构：

[1] Univ Fed Parana, Hosp Vet, BR-85950000 Palotina, PR, Brazil

[2] MAPA, Ribeirao Preto, SP, Brazil

[3] Med Vet Autonoma, Campinas, SP, Brazil

[4] Univ Estadual Paulista, Dept Clin & Cirurgia Vet, Jaboticabal, SP, Brazil

来源：

CIENCIA RURAL | 2011年 / 41卷 / 10期

关键词：

clonidine; epidural; horses; morphine; nociception; xylazine; HYDROCHLORIDE SOLUTION; ADMINISTERED XYLAZINE; POSTOPERATIVE PAIN; ANALGESIA; MARES;

D O I：

暂无

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Opioids and alpha(2)-agonists have analgesic effect and preventive administration by epidural route can minimize undesirable and clinical effects. So, behavioral, clinical and analgesic effects were evaluated for 24 hours after preventive epidural injection of morphine (0.1mg kg(-1)), xylazine (0.17mg kg(-1)) or clonidine (3 mu g kg(-1)) in 18 horses subjected to incisional model of inflammatory pain evaluated by von Frey filaments. Behavioral changes and changes in heart rate, respiratory rate, rectal temperature and height of head were minimum and transitory. Cutaneous sensivity in injured skin was similar to complete skin for 24, 8 and 12 hours after preventive epidural injection of morphine, xylazine and clonidine, respectively. Moreover, clinical and behavioral changes were not severe along 24 hours.

引用

页码：1790 / 1796

页数：7

共 28 条

[1] Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy - A randomized double-blind study
Aida, S
Yamakura, T
Baba, H
Taga, K
Fukuda, S
Shimoji, K
[J]. ANESTHESIOLOGY, 2000, 92 (06) : 1624 - 1630
[2] PHARMACOKINETICS AND DYNAMICS OF INTRAVENOUS, INTRATHECAL, AND EPIDURAL CLONIDINE IN SHEEP
CASTRO, MI
EISENACH, JC
[J]. ANESTHESIOLOGY, 1989, 71 (03) : 418 - 425
[3] Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a pat model of postoperative pain
Cheng, JK
Pan, HL
Eisenach, JC
[J]. ANESTHESIOLOGY, 2000, 92 (04) : 1126 - 1131
[4] Effect of caudal epidural xylazine on intraoperative distress and post-operative pain in Holstein heifers
Chevalier, HM
Provost, PJ
Karas, AZ
[J]. VETERINARY ANAESTHESIA AND ANALGESIA, 2004, 31 (01) : 1 - 10
[5] CHRUBASIK J, 1993, EUR J ANAESTH, V10, P79
[6] Perineal analgesic actions of epidural clonidine in cattle
De Rossi, R
Bucker, GV
Varela, JV
[J]. VETERINARY ANAESTHESIA AND ANALGESIA, 2003, 30 (02) : 64 - 71
[7] De Rossi R, 2001, HORA VET, V120, P49
[8] Comparative study of epidural xylazine or clonidine in horses
Doria, Renata G. S.
Valadao, Carlos A. A.
Duque, Juan C.
Farias, Anderson
Almeida, Ricardo M.
Netto, Augusto Castro
[J]. VETERINARY ANAESTHESIA AND ANALGESIA, 2008, 35 (02) : 166 - 172
[9] alpha(2)-adrenergic agonists for regional anesthesia - A clinical review of clonidine (1984-1995)
Eisenach, JC
DeKock, M
Klimscha, W
[J]. ANESTHESIOLOGY, 1996, 85 (03) : 655 - 674
[10] EPIDURAL CLONIDINE ANALGESIA FOR INTRACTABLE CANCER PAIN - PHASE-I
EISENACH, JC
RAUCK, RL
BUZZANELL, C
LYSAK, SZ
[J]. ANESTHESIOLOGY, 1989, 71 (05) : 647 - 652

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