Facile Synthesis of 5-Trifluoromethyl-2,4-disubstituted Oxazoles via a Copper(II)-Catalyzed and TBHP/I2-Mediated Tandem Oxidative Cyclization

被引：8

作者：

Wei Song ^{[1
]}

Yu Haigang ^{[1
]}

Chen Jie ^{[1
]}

Deng Hongmei ^{[4
]}

Zhang Hui ^{[1
]}

Cao Weiguo ^{[1
,2
,3
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[4] Shanghai Univ, Lab Microstruct, Shanghai 200444, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2011年 / 29卷 / 12期

基金：

中国国家自然科学基金;

关键词：

trifluoromethyl; oxazole synthesis; tandem oxidative cyclization; ONE-POT SYNTHESIS; TRIFLUOROMETHYL; HETEROCYCLES; ROUTE; ACID;

D O I：

10.1002/cjoc.201100281

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of Cu(OAc)(2)center dot H2O, a variety of 5-trifluoromethyl-2,4-disubstituted oxazoles were easily synthesized via t-BuOOH (TBHP)/I-2-mediated tandem oxidative cyclization from readily available starting materials aryl methanamines and alpha-trifluoroacetyl-substituted ketones or esters under mild conditions. The mechanism was proposed.

引用

页码：2619 / 2624

页数：6

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