Facile Synthesis of 5-Trifluoromethyl-2,4-disubstituted Oxazoles via a Copper(II)-Catalyzed and TBHP/I2-Mediated Tandem Oxidative Cyclization

被引：8
|
作者：
Wei Song [1 ]
Yu Haigang [1 ]
Chen Jie [1 ]
Deng Hongmei [4 ]
Zhang Hui [1 ]
Cao Weiguo [1 ,2 ,3 ]
机构：
[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[4] Shanghai Univ, Lab Microstruct, Shanghai 200444, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2011年 / 29卷 / 12期
基金：
中国国家自然科学基金;
关键词：
trifluoromethyl; oxazole synthesis; tandem oxidative cyclization; ONE-POT SYNTHESIS; TRIFLUOROMETHYL; HETEROCYCLES; ROUTE; ACID;
D O I：
10.1002/cjoc.201100281
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the presence of Cu(OAc)(2)center dot H2O, a variety of 5-trifluoromethyl-2,4-disubstituted oxazoles were easily synthesized via t-BuOOH (TBHP)/I-2-mediated tandem oxidative cyclization from readily available starting materials aryl methanamines and alpha-trifluoroacetyl-substituted ketones or esters under mild conditions. The mechanism was proposed.
引用
收藏
页码：2619 / 2624
页数：6
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