Leukemia Gene Atlas - A Public Platform for Integrative Exploration of Genome-Wide Molecular Data

被引：46

作者：

Hebestreit, Katja ^{[1
]}

Groettrup, Soeren ^{[1
]}

Emden, Daniel ^{[1
]}

Veerkamp, Jannis ^{[1
]}

Ruckert, Christian ^{[1
]}

Klein, Hans-Ulrich ^{[1
]}

Mueller-Tidow, Carsten ^{[2
]}

Dugas, Martin ^{[1
]}

机构：

[1] Univ Munster, Inst Med Informat, Munster, Germany

[2] Univ Munster, Dept Med Hematol & Oncol, Munster, Germany

来源：

PLOS ONE | 2012年 / 7卷 / 06期

关键词：

CANCER; HEMATOPOIESIS; MUTATIONS; PATHWAYS; ONCOLOGY; RUNX1;

D O I：

10.1371/journal.pone.0039148

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leukemias are exceptionally well studied at the molecular level and a wealth of high-throughput data has been published. But further utilization of these data by researchers is severely hampered by the lack of accessible integrative tools for viewing and analysis. We developed the Leukemia Gene Atlas (LGA) as a public platform designed to support research and analysis of diverse genomic data published in the field of leukemia. With respect to leukemia research, the LGA is a unique resource with comprehensive search and browse functions. It provides extensive analysis and visualization tools for various types of molecular data. Currently, its database contains data from more than 5,800 leukemia and hematopoiesis samples generated by microarray gene expression, DNA methylation, SNP and next generation sequencing analyses. The LGA allows easy retrieval of large published data sets and thus helps to avoid redundant investigations. It is accessible at www.leukemia-gene-atlas.org.

引用

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