Common polymorphisms in the coding part of the IL4-receptor gene

被引：99

作者：

Deichmann, K

Bardutzky, J

Forster, J

Heinzmann, A

Kuehr, J

机构：

[1] University Children's Hospital, University of Freiburg, D 79106 Freiburg

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 231卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.6115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present 12 common polymorphisms in the coding part of the IL4 receptor gene, 5 of them leading to amino acid changes of the gene product. The IL4-receptor represents a membrane bound protein on T-cells binding the cytokine IL4 and mediating its effect. The polymorphisms and mutations described here might be useful to shed light on the structure and functioning of the IL4 receptor. Furthermore, the protein represents a candidate gene for several immunological disorders involving the IL4 pathway. (C) 1997 Academic Press.

引用

页码：696 / 697

页数：2

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