One-Pot Synthesis of Symmetrical 2,6-Diarylpyridines via Palladium/Copper-Catalyzed Sequential Decarboxylative and Direct C-H Arylation

被引：16
|
作者：
Ma, Zhiyong [1 ]
Liu, Hailong [1 ]
Zhang, Chunchun [2 ]
Zheng, Xueli [1 ]
Yuan, Maolian [1 ]
Fu, Haiyan [1 ]
Li, Ruixiang [1 ]
Chen, Hua [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 06期
关键词：
C-H functionalization; decarboxylation; 2,6-diarylpyridines; dimethyl sulfate; palladium; CROSS-COUPLING REACTIONS; BOND ARYLATION; PYRIDINES; HETEROCYCLES; COMPLEXES; PALLADATION; OLEFINATION; ALKYLATION; ACETATES; ACIDS;
D O I：
10.1002/adsc.201400900
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A palladium(II)/copper oxide (Cu2O)-catalyzed one-pot decarboxylative and direct C-H arylation of 2-picolinic acid with aryl bromides has been developed. Various aryl bromides have been shown to be efficient coupling partners in the presence of dimethyl sulfate, furnishing symmetrical 2,6-diarylpyridines in moderate to good yields.
引用
收藏
页码：1143 / 1148
页数：6
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