One-Pot Synthesis of Symmetrical 2,6-Diarylpyridines via Palladium/Copper-Catalyzed Sequential Decarboxylative and Direct C-H Arylation

被引：16

作者：

Ma, Zhiyong ^{[1
]}

Liu, Hailong ^{[1
]}

Zhang, Chunchun ^{[2
]}

Zheng, Xueli ^{[1
]}

Yuan, Maolian ^{[1
]}

Fu, Haiyan ^{[1
]}

Li, Ruixiang ^{[1
]}

Chen, Hua ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 06期

关键词：

C-H functionalization; decarboxylation; 2,6-diarylpyridines; dimethyl sulfate; palladium; CROSS-COUPLING REACTIONS; BOND ARYLATION; PYRIDINES; HETEROCYCLES; COMPLEXES; PALLADATION; OLEFINATION; ALKYLATION; ACETATES; ACIDS;

D O I：

10.1002/adsc.201400900

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A palladium(II)/copper oxide (Cu2O)-catalyzed one-pot decarboxylative and direct C-H arylation of 2-picolinic acid with aryl bromides has been developed. Various aryl bromides have been shown to be efficient coupling partners in the presence of dimethyl sulfate, furnishing symmetrical 2,6-diarylpyridines in moderate to good yields.

引用

页码：1143 / 1148

页数：6

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