LDL-Cholesterol: From the Hypothesis to Causality

被引：6
作者：
Custodis, Florian [1 ]
Laufs, Ulrich [1 ]
机构：
[1] Univ Klinikum Saarlandes, Abt Innere Med Kardiol Angiol & Internist Intensi, Homburg, Germany
来源：
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2015年 / 140卷 / 10期
关键词：
LDL; Cholesterol; LDL-Hypothesis; IMPROVE-IT; CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; IMPROVE-IT; TRIALS; RISK; HYPERCHOLESTEROLEMIA; METAANALYSIS; SIMVASTATIN; PREVENTION; REDUCTION;
D O I：
10.1055/s-0041-102254
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The term "LDL-Hypothesis is frequently used to describe the association between LDL cholesterol (LDL-C) and cardiovascular outcomes. In the light of recent results of randomized trials the question arises whether the term hypothesis is still adequate. Considering the causal importance of LDL for the pathogenesis of atherosclerosis, epidemiological evidence and the clear genetic association of LDL-C with cardiovascular risk as well as the large statin trials and the reduction of events by a non-statin intervention in the IMPROVE-IT study, the term hypothesis appears to be outdated and should be replaced by LDL-causality.
引用
收藏
页码：761 / U71
页数：5
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共 17 条
  • [11] Understanding IMPROVE-IT and the cardinal role of LDL-C lowering in CVD prevention
    Laufs, Ulrich
    Descamps, Olivier S.
    Catapano, Alberico L.
    Packard, Chris J.
    [J]. EUROPEAN HEART JOURNAL, 2014, 35 (30) : 1996 - 2000
  • [12] Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis
    Nicholls, Stephen J.
    Tuzcu, E. Murat
    Sipahi, Ilke
    Grasso, Adam W.
    Schoenhagen, Paul
    Hu, Tingfei
    Wolski, Kathy
    Crowe, Tim
    Desai, Milind Y.
    Hazen, Stanley L.
    Kapadia, Samir R.
    Nissen, Steven E.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (05): : 499 - 508
  • [13] Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
    Schulz, Rainer
    Schlueter, Klaus-Dieter
    Laufs, Ulrich
    [J]. BASIC RESEARCH IN CARDIOLOGY, 2015, 110 (02)
  • [14] PREVENTION OF CORONARY HEART-DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA
    SHEPHERD, J
    COBBE, SM
    FORD, I
    ISLES, CG
    LORIMER, AR
    MACFARLANE, PW
    MCKILLOP, JH
    PACKARD, CJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (20) : 1301 - 1307
  • [15] Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
    Stitziel, Nathan O.
    Won, Hong-Hee
    Morrison, Alanna C.
    Peloso, Gina M.
    Do, Ron
    Lange, Leslie A.
    Fontanillas, Pierre
    Gupta, Namrata
    Duga, Stefano
    Goel, Anuj
    Farrall, Martin
    Saleheen, Danish
    Ferrario, Paola
    Koenig, Inke
    Asselta, Rosanna
    Merlini, Piera A.
    Marziliano, Nicola
    Notarangelo, Maria Francesca
    Schick, Ursula
    Auer, Paul
    Assimes, Themistocles L.
    Reilly, Muredach
    Wilensky, Robert
    Rader, Daniel J.
    Hovingh, G. Kees
    Meitinger, Thomas
    Kessler, Thorsten
    Kastrati, Adnan
    Laugwitz, Karl-Ludwig
    Siscovick, David
    Rotter, Jerome I.
    Hazen, Stanley L.
    Tracy, Russell
    Cresci, Sharon
    Spertus, John
    Jackson, Rebecca
    Schwartz, Stephen M.
    Natarajan, Pradeep
    Crosby, Jacy
    Muzny, Donna
    Ballantyne, Christie
    Rich, Stephen S.
    O'Donnell, Christopher J.
    Abecasis, Goncalo
    Sunyaev, Shamil
    Nickerson, Deborah A.
    Buring, Julie E.
    Ridker, Paul M.
    Chasman, Daniel I.
    Austin, Erin
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (22) : 2072 - 2082
  • [16] 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    Stone, Neil J.
    Robinson, Jennifer G.
    Lichtenstein, Alice H.
    Merz, C. Noel Bairey
    Blum, Conrad B.
    Eckel, Robert H.
    Goldberg, Anne C.
    Gordon, David
    Levy, Daniel
    Lloyd-Jones, Donald M.
    McBride, Patrick
    Schwartz, J. Sanford
    Shero, Susan T.
    Smith, Sidney C., Jr.
    Watson, Karol
    Wilson, Peter W. F.
    [J]. CIRCULATION, 2014, 129 (25) : S1 - S45
  • [17] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
    Voight, Benjamin F.
    Peloso, Gina M.
    Orho-Melander, Marju
    Frikke-Schmidt, Ruth
    Barbalic, Maja
    Jensen, Majken K.
    Hindy, George
    Holm, Hilma
    Ding, Eric L.
    Johnson, Toby
    Schunkert, Heribert
    Samani, Nilesh J.
    Clarke, Robert
    Hopewell, Jemma C.
    Thompson, John F.
    Li, Mingyao
    Thorleifsson, Gudmar
    Newton-Cheh, Christopher
    Musunuru, Kiran
    Pirruccello, James P.
    Saleheen, Danish
    Chen, Li
    Stewart, Alexandre F. R.
    Schillert, Arne
    Thorsteinsdottir, Unnur
    Thorgeirsson, Gudmundur
    Anand, Sonia
    Engert, James C.
    Morgan, Thomas
    Spertus, John
    Stoll, Monika
    Berger, Klaus
    Martinelli, Nicola
    Girelli, Domenico
    McKeown, Pascal P.
    Patterson, Christopher C.
    Epstein, Stephen E.
    Devaney, Joseph
    Burnett, Mary-Susan
    Mooser, Vincent
    Ripatti, Samuli
    Surakka, Ida
    Nieminen, Markku S.
    Sinisalo, Juha
    Lokki, Marja-Liisa
    Perola, Markus
    Havulinna, Aki
    de Faire, Ulf
    Gigante, Bruna
    Ingelsson, Erik
    [J]. LANCET, 2012, 380 (9841) : 572 - 580
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