LDL-Cholesterol: From the Hypothesis to Causality

被引：6
作者：
Custodis, Florian [1 ]
Laufs, Ulrich [1 ]
机构：
[1] Univ Klinikum Saarlandes, Abt Innere Med Kardiol Angiol & Internist Intensi, Homburg, Germany
来源：
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2015年 / 140卷 / 10期
关键词：
LDL; Cholesterol; LDL-Hypothesis; IMPROVE-IT; CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; IMPROVE-IT; TRIALS; RISK; HYPERCHOLESTEROLEMIA; METAANALYSIS; SIMVASTATIN; PREVENTION; REDUCTION;
D O I：
10.1055/s-0041-102254
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The term "LDL-Hypothesis is frequently used to describe the association between LDL cholesterol (LDL-C) and cardiovascular outcomes. In the light of recent results of randomized trials the question arises whether the term hypothesis is still adequate. Considering the causal importance of LDL for the pathogenesis of atherosclerosis, epidemiological evidence and the clear genetic association of LDL-C with cardiovascular risk as well as the large statin trials and the reduction of events by a non-statin intervention in the IMPROVE-IT study, the term hypothesis appears to be outdated and should be replaced by LDL-causality.
引用
收藏
页码：761 / U71
页数：5
相关论文
共 17 条
  • [1] Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    Baigent, C
    Keech, A
    Kearney, PM
    Blackwell, L
    Buck, G
    Pollicino, C
    Kirby, A
    Sourjina, T
    Peto, R
    Collins, R
    Simes, J
    [J]. LANCET, 2005, 366 (9493) : 1267 - 1278
  • [2] Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population
    Blazing, Michael A.
    Giugliano, Robert P.
    Cannon, Christopher P.
    Musliner, Thomas A.
    Tershakovec, Andrew M.
    White, Jennifer A.
    Reist, Craig
    McCagg, Amy
    Braunwald, Eugene
    Califf, Robert M.
    [J]. AMERICAN HEART JOURNAL, 2014, 168 (02) : 205 - +
  • [3] Very Low Levels of Atherogenic Lipoproteins and the Risk for Cardiovascular Events A Meta-Analysis of Statin Trials
    Boekholdt, S. Matthijs
    Hovingh, G. Kees
    Mora, Samia
    Arsenault, Benoit J.
    Amarenco, Pierre
    Pedersen, Terje R.
    LaRosa, John C.
    Waters, David D.
    DeMicco, David A.
    Simes, R. John
    Keech, Antony C.
    Colquhoun, David
    Hitman, Graham A.
    Betteridge, John
    Clearfield, Michael B.
    Downs, John R.
    Colhoun, Helen M.
    Gotto, Antonio M., Jr.
    Ridker, Paul M.
    Grundy, Scott M.
    Kastelein, John J. P.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (05) : 485 - 494
  • [4] Premature Release of Data from Clinical Trials of Ezetimibe
    Califf, Robert M.
    Harrington, Robert A.
    Blazing, Michael A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (07) : 712 - 717
  • [5] Cannon C P, 2014, IMPROVE IT TRIAL COM
  • [6] Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
    Cannon, Christopher P.
    Giugliano, Robert P.
    Blazing, Michael A.
    Harrington, Robert A.
    Peterson, John L.
    Sisk, Christine McCrary
    Strony, John
    Musliner, Thomas A.
    McCabe, Carolyn H.
    Veltri, Enrico
    Braunwald, Eugene
    Califf, Robert M.
    [J]. AMERICAN HEART JOURNAL, 2008, 156 (05) : 826 - 832
  • [7] Ference B A, 2015, J AM COLL CARDIOL
  • [8] Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease A Mendelian Randomization Analysis
    Ference, Brian A.
    Yoo, Wonsuk
    Alesh, Issa
    Mahajan, Nitin
    Mirowska, Karolina K.
    Mewada, Abhishek
    Kahn, Joel
    Afonso, Luis
    Williams, Kim Allan, Sr.
    Flack, John M.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (25) : 2631 - 2639
  • [9] SERUM CHOLESTEROL, LIPOPROTEINS, AND RISK OF CORONARY HEART DISEASE - FRAMINGHAM STUDY
    KANNEL, WB
    CASTELLI, WP
    GORDON, T
    MCNAMARA, PM
    [J]. ANNALS OF INTERNAL MEDICINE, 1971, 74 (01) : 1 - +
  • [10] Familial Hypercholesterolemia: Developments in Diagnosis and Treatment
    Klose, Gerald
    Laufs, Ulrich
    Maerz, Winfried
    Windler, Eberhard
    [J]. DEUTSCHES ARZTEBLATT INTERNATIONAL, 2014, 111 (31-32): : 523 - +
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