Vaspin - a link of obesity and psoriasis?

被引：32

作者：

Saalbach, Anja ^{[1
]}

Vester, Katharina ^{[1
]}

Rall, Kathrin ^{[1
]}

Tremel, Jenny ^{[1
,3
]}

Anderegg, Ulf ^{[1
]}

Beck-Sickinger, Annette G. ^{[2
,3
]}

Blueher, Matthias ^{[3
,4
]}

Simon, Jan C. ^{[1
,3
]}

机构：

[1] Univ Leipzig, Fac Med, Dept Dermatol Venerol & Allergol, D-04103 Leipzig, Germany

[2] Univ Leipzig, Fac Life Sci Pharm & Psychol, Inst Biochem, D-04103 Leipzig, Germany

[3] Univ Leipzig, Fac Life Sci, LIFE Leipzig Res Ctr Civilizat, D-04103 Leipzig, Germany

[4] Univ Leipzig, Fac Med, Dept Med, D-04103 Leipzig, Germany

来源：

EXPERIMENTAL DERMATOLOGY | 2012年 / 21卷 / 04期

关键词：

psoriasis; skin; vaspin; SERINE-PROTEASE INHIBITOR; ADIPOSE-TISSUE; ADIPOCYTOKINE;

D O I：

10.1111/j.1600-0625.2012.01460.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is an inflammatory skin disease often associated with obesity. The anti-inflammatory adipokine vaspin, a suggested serine proteinase inhibitor of the serpin family, is discussed as a new link between inflammation and obesity. Here, we demonstrate that different from healthy controls vaspin serum levels in patients with psoriasis were body mass index independent. Moreover, we could identify keratinocytes as the major source of vaspin in skin. Vaspin expression in lesional psoriatic skin was reduced compared with uninvolved skin as shown by immunohistochemistry and RT-PCR. In aggregate, we report on the cellular source of vaspin in skin and its expression in psoriasis.

引用

页码：309 / 312

页数：4

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