The preparation of (EtO)2P(O)CFHZnBr and (EtO)2P(O)CFHCu and their utility in the preparation of functionalized α-fluorophosphonates

被引：41
作者：
Zhang, X [1 ]
Qiu, WM [1 ]
Burton, DJ [1 ]
机构：
[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0040-4039(99)00305-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The organometallic reagent, (EtO)(2)P(O)CFHZnBr, was generated in situ in excellent yields via the reaction of (EtO)(2)P(O)CFHBr with zinc metal. Metathesis with Cu(I)Br gate (EtO)(2)P(O)CFHCu. The reagents exhibit excellent reactivity with substrates, such as allyl halides, alkynyl halides, vinyl halides, aryl halides and acyl or phosphoryl halides, and provide a useful one flask route to functionalized alpha-fluorophosphonates. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2681 / 2684
页数：4
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