Objective: Outcomes of surgery for otitis media and cholesteatoma according to the graft materials for mastoid obliteration were compared, and their compatibility as mastoid obliteration materials was examined. Materials and Methods: Among patients performed mastoid obliteration during the first surgery or revision for otitis media or cholesteatoma from January 2007 to April 2010, 191 patients, 196 ears, whose follow-up observation period was longer than 6 months were selected. The male was 72 patients (74 ears), and the female was 119 patients (122 ears). The age distribution was 9 - 78 years, and the mean age was 45.5 years. The follow-up observation period was average 15 months. Used for mastoid obliteration surgery were autogenous bone, allogeneic bone and hydroxylapatite (HA) and we divided patients into three groups according to graft materials. The rate of graft failure and complications were examined. Complications were divided into mastoid and tympanic cavity complications. Results: The rate of graft failure in HA group was highest in both CWU and CWD surgery. In autogenous bones group was 0.8 %, which was lowest and allogeneic bone group, it was 3.1 %, and good results comparable to autogenous bone group. In regard to mastoid and tympanic cavity complication, HA group also showed highest rate (10% and 16.7% respectively). Conclusion: In mastoid obliteration, HA was high rate of graft failure and complications. Thus it was determined to be not compatible any more. In contrast, allogeneic bone hardly induced problems comparable to autogenous bone. Therefore, it is judged that for cases whose autogenous bone for mastoid obliteration is not sufficient or available, allogeneic bones could be used as safe substitute materials.