Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma

被引：24
作者：
Zhang, Ning [1 ,2 ,3 ,4 ]
Xu, Jing [2 ,3 ,4 ]
Jiang, Congshan [5 ]
Lu, Shemin [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Natl Joint Engn Res Ctr Biodiagnost & Biotherapy, Xian, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Key Lab Environm & Genes Related Dis, Minist Educ, Xian, Shaanxi, Peoples R China
[3] Xian Jiaotong Univ Hlth Sci Ctr, Inst Mol & Translat Med IMTM, Xian, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hlth Sci Ctr, Xian, Shaanxi, Peoples R China
[5] Xi An Jiao Tong Univ, Xian Childrens Hosp, Shaanxi Inst Pediat Dis, Natl Reg Childrens Med Ctr Northwest,Affiliated C, Xian, Shaanxi, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
neuro-immune regulation; inflammation; airway remodeling; asthma; pulmonary neuroendocrine cells; NERVE GROWTH-FACTOR; PULMONARY NEUROENDOCRINE CELLS; INNATE LYMPHOID-CELLS; NEUROEPITHELIAL BODIES; PRODUCE NEUROTROPHINS; MOUSE MODEL; GUINEA-PIG; LUNG; EOSINOPHILS; EXPRESSION;
D O I：
10.3389/fimmu.2022.894047
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Allergic asthma is a common chronic inflammation of the airways and causes airway remodeling eventually. For a long time, investigators have been focusing on the immunological mechanism of asthma. However, in recent years, the role of neuro-regulation in the occurrence of asthma has gradually attracted investigators' attention. In this review, we firstly describe neuro-immune regulation in inflammation of allergic asthma from two aspects: innate immunity and adaptive immunity. Secondly, we introduce neuro-immune regulation in airway remodeling of asthma. Finally, we prospect the role of pulmonary neuroendocrine cells in the development of asthma. In general, the amount of researches is limited. Further researches on the neural regulation during the occurrence of asthma will help us clarify the mechanism of asthma more comprehensively and find more effective ways to prevent and control asthma.
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页数：10
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