Anti-BCMA CAR-T cells therapy for a patient with extremely high membrane BCMA expression: a case report

被引：10

作者：

Li, Dan ^{[1
,2
]}

Que, Yimei ^{[1
]}

Ding, Shengnan ^{[1
,2
]}

Hu, Guang ^{[3
]}

Wang, Wen ^{[3
]}

Mao, Xia ^{[1
,2
]}

Wang, Ying ^{[1
,2
]}

Li, Chunrui ^{[1
,2
]}

Huang, Liang ^{[1
,2
]}

Zhou, Jianfeng ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

Xiao, Min ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Hubei, Peoples R China

[2] Immunotherapy Res, Immunotherapy Res Ctr Hematol Dis Hubei Prov, Wuhan, Hubei, Peoples R China

[3] Nanjing IASO Biotherapeut Ltd, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2022年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

PRESENILIN;

D O I：

10.1136/jitc-2022-005403

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B cell maturation antigen (BCMA)-directed CAR-T cell therapy is a disruptive approach for treating relapsed/ refractory multiple myeloma (R/R MM); however, optimization is necessary to maximize patient benefit. We report the case of a 61-year-old woman with primary refractory MM who presented with high expression of membrane BCMA and low expression of soluble BCMA (sBCMA), experienced grade 4 cytokine release syndrome, and died fromsevere pneumonia after receiving anti-BCMA CAR-T (CT103A) therapy. This case highlights the importance of assessing the expression range of BCMA for its efficacy and safety in patients receiving BCMA CAR-T therapy. For patients who present with extremely high membrane BCMA expression and extremely low sBCMA expression, the presence of i-secretase-related gene mutations should be considered. Special attention should also be paid to the prevention and treatment of cytokine release syndrome in such patients.

引用

页数：5

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