A Metal-Free Oxidative Amination of Benzoxazoles with Primary Amines and Ammonia

被引：41

作者：

Kloeckner, Ulrich ^{[1
]}

Weckenmann, Nicole M. ^{[1
]}

Nachtsheim, Boris J. ^{[1
]}

机构：

[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

来源：

SYNLETT | 2012年 / 23卷 / 01期

关键词：

green chemistry; amination; homogeneous catalysis; iodine; oxidation; C-H BONDS; CATALYZED DIRECT AMINATION; ACTIVATION REACTIONS; FUNCTIONALIZATION; AMIDATION; AZOLES; BENZIMIDAZOLES; TEMPERATURE; FORMAMIDES; SP(2);

D O I：

10.1055/s-0031-1289902

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 2-aminobenzoxazoles is described by a direct oxidative amination of unfunctionalized benzoxazoles with primary amines. The reaction could be performed in the absence of transition metals by using catalytic amounts of a quaternary ammonium iodide and tert-butylhydroperoxide as a cheap and easy-to-handle co-oxidant. In addition to primary amines, aqueous solutions of NH3 were used to introduce a primary amine group into the heterocyclic core.

引用

页码：97 / 100

页数：4

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