PCAT-1: A pivotal oncogenic long non-coding RNA in human cancers

被引：18

作者：

Yang, Zhi ^{[1
]}

Zhao, Shan ^{[2
]}

Zhou, Xiangyu ^{[1
]}

Zhao, Haiying ^{[1
]}

Jiang, Xiaofeng ^{[1
]}

机构：

[1] China Med Univ, Dept Gen Surg, Affiliated Hosp 4, Chongshan East Rd 4, Shenyang 110032, Liaoning, Peoples R China

[2] China Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 110卷

基金：

中国国家自然科学基金;

关键词：

Long non-coding RNA; PCAT-1; Cancer; Oncogene; Prognosis; EXPRESSION PROMOTES PROLIFERATION; GENOME-WIDE ASSOCIATION; POOR-PROGNOSIS; LNCRNA PCAT1; HOMOLOGOUS RECOMBINATION; CELL-PROLIFERATION; BREAST-CANCER; GROWTH ARREST; UP-REGULATION; MYC;

D O I：

10.1016/j.biopha.2018.12.014

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Prostate cancer-associated transcript 1 (PCAT-1) is a newly identified long non-coding RNA comprising two exons, located in the Chr8q24 gene desert approximately 725 kb upstream of the MYC oncogene. PCAT-1 is dysregulated and acts as an oncogene in different types of cancers and has been implicated in several processes correlated with carcinogenesis, such as cell proliferation, invasion, metastasis, apoptosis, cell cycle, chemoresistance, and homologous recombination. The mechanisms underlying the effects of PCAT-1 are complex and involve multiple factors and signaling pathways. In this paper, we systematically review the multiple pathological functions of PCAT-1 in diverse malignancies to elucidate its potential molecular mechanisms and to provide new directions for future research.

引用

页码：493 / 499

页数：7

共 81 条

[1] BRCA2 regulates homologous recombination in response to DNA damage: Implications for genome stability and carcinogenesis [J].

Abaji, C ;

Cousineau, I ;

Belmaaza, A .

CANCER RESEARCH, 2005, 65 (10) :4117-4125

[2] DNA double-strand break repair pathway choice and cancer [J].

Aparicio, Tomas ;

Baer, Richard ;

Gautier, Jean .

DNA REPAIR, 2014, 19 :169-175

[3]

Arita T, 2013, ANTICANCER RES, V33, P3185

[4] Long non-coding RNA PCAT-1 over-expression promotes proliferation and metastasis in gastric cancer cells through regulating CDKN1A [J].

Bi, Mingjun ;

Yu, Hongmei ;

Huang, Bin ;

Tang, Cuiyan .

GENE, 2017, 626 :337-343

[5] Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer [J].

Cao, Qi ;

Mani, Ram-Shankar ;

Ateeq, Bushra ;

Dhanasekaran, Saravana M. ;

Asangani, Irfan A. ;

Prensner, John R. ;

Kim, Jung H. ;

Brenner, J. Chad ;

Jing, Xiaojun ;

Cao, Xuhong ;

Wang, Rui ;

Li, Yong ;

Dahiya, Arun ;

Wang, Lei ;

Pandhi, Mithil ;

Lonigro, Robert J. ;

Wu, Yi-Mi ;

Tomlins, Scott A. ;

Palanisamy, Nallasivam ;

Qin, Zhaohui ;

Yu, Jindan ;

Maher, Christopher A. ;

Varambally, Sooryanarayana ;

Chinnaiyan, Arul M. .

CANCER CELL, 2011, 20 (02) :187-199

[6] Role of histone H3 lysine 27 methylation in polycomb-group silencing [J].

Cao, R ;

Wang, LJ ;

Wang, HB ;

Xia, L ;

Erdjument-Bromage, H ;

Tempst, P ;

Jones, RS ;

Zhang, Y .

SCIENCE, 2002, 298 (5595) :1039-1043

[7] Long noncoding RNAs in cell biology [J].

Clark, Michael B. ;

Mattick, John S. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2011, 22 (04) :366-376

[8]

Cui WC, 2017, EUR REV MED PHARMACO, V21, P3021

[9] Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond [J].

Curtin, Nicola J. ;

Szabo, Csaba .

MOLECULAR ASPECTS OF MEDICINE, 2013, 34 (06) :1217-1256

[10] MYC on the Path to Cancer [J].

Dang, Chi V. .

CELL, 2012, 149 (01) :22-35

← 1 2 3 4 5 6 7 8 9 →