Location, Location, Location: FoxM1 Mediates β-Catenin Nuclear Translocation and Promotes Glioma Tumorigenesis

被引：38

作者：

Bowman, Angela ^{[1
]}

Nusse, Roel ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Dev Biol, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

CANCER CELL | 2011年 / 20卷 / 04期

关键词：

EXPRESSION; TARGET;

D O I：

10.1016/j.ccr.2011.10.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic alterations in the Wnt/beta-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates beta-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/beta-catenin pathway activation.

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收藏

页码：415 / 416

页数：2

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