Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease

被引:10
作者
Sahin, S. [1 ]
Ceyhan, K. [3 ]
Benli, I. [1 ]
Ozyurt, H. [1 ]
Naseri, E. [2 ]
Tumuklu, M. M. [3 ]
Aydogan, L. [1 ]
Elalmis, A. O. [2 ]
Ozugurlu, A. F. [1 ]
Onalan, O. [3 ]
机构
[1] Gaziosmanpasa Univ, Fac Med, Dept Biochem, Tokat, Turkey
[2] Gaziosmanpasa Univ, Fac Med, Dept Cardiovasc Surg, Tokat, Turkey
[3] Gaziosmanpasa Univ, Fac Med, Dept Cardiol, Tokat, Turkey
关键词
Angiotensin-converting enzyme; Coronary artery disease; Polymorphism; HEART-DISEASE; MYOCARDIAL-INFARCTION; DELETION POLYMORPHISM; VASCULAR HYPERTROPHY; ATHEROSCLEROSIS; OUTCOMES; ALLELE; SYSTEM;
D O I
10.4238/2015.March.20.16
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, the ACE (I/D) gene polymorphism, and ACE serum levels were compared. ACE genotypes were determined using real-time polymerase chain reaction. ACE serum levels were determined using an enzyme-linked immunosorbent assay. Lipid parameters were determined spectrophotometrically using an autoanalyzer. Compared to the control group, the CAD group showed significantly higher serum ACE levels (P < 0.001). The highest ACE levels were found in those with the DD genotype. Other genotypes also presented statistically significant differences. We observed a significant difference between the control and coronary patient groups regarding the levels of total cholesterol, triglyceride, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol (P < 0.05). ACE (I/D) genotypes and serum ACE levels may be associated with risk factors and the development of CAD.
引用
收藏
页码:2063 / 2068
页数:6
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