Alkaloids of the Papaveraceae .96. Alkaloids of Meconopsis cambrica (L) Vig and M-robusta Hook f et Thoms

Additional alkaloids (+)-roemerine (3b), (+)-corytuberine (3d), (-)-N-methylmecambridinium and alkaloid MC 2 (the last two as iodides) were isolated as minor alkaloidal components from Meconopsis cambrica (L.) VIG. (Papaveraceae) besides of the dominant known alkaloids (-)-mecambrine (1), (-)-mecambridine (2), (-)-flavinantine (4) and (+)-magnoflorine (5), and a small amount of (+)-mecambroline (3a). Minute quantities of protopine, allocryptopine, roemeroline, papaverrubine D and C, berberine, coptisine, corysamine and palmatine were identified by thin layer chromatography (TLC). From M. robusta HOOK. f. et THOMS., protopine, (-)-amurensinine (6) and two incompletely characterized alkaloids MRO 1 and MRO 2 were isolated, and allocryptopine, crytopine, rhoeadine, 6-methoxy-2-methyl-1,2,3,4-tetrahydro-beta-carboline, alkaloid MR I, coptisine, corysamine, magnoflorine, corytuberine and N-methylamurensininium salt were detected on TLC.