DNA interaction, antimicrobial, electrochemical and spectroscopic studies of metal(II) complexes with tridentate heterocyclic Schiff base derived from 2′-methylacetoacetanilide

被引：91

作者：

Raman, Natarajan ^{[1
]}

Pothiraj, Krishnan ^{[1
]}

Baskaran, Thanasekaran ^{[1
]}

机构：

[1] VHNSN Coll, Dept Chem Res, Virudunagar 626001, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2011年 / 1000卷 / 1-3期

关键词：

Schiff base; Metal(II) complexes; DNA binding; Antimicrobial activity; COPPER(II) COMPLEXES; RUTHENIUM COMPLEXES; CRYSTAL-STRUCTURE; BINDING; ANTIBACTERIAL; LIGAND; TRIS(PHENANTHROLINE)RUTHENIUM(II); ANTIFUNGAL; NICKEL(II); COBALT(II);

D O I：

10.1016/j.molstruc.2011.06.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new Schiff base ligand (HL) was synthesized by the condensation reaction between 2'-methyleacetoacetanilide and 2-amino-3-hydroxypyridine. Its Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared by the interaction of the ligand with metal(II) chloride. They were characterized by elemental analysis, IR, H-1 NMR, EPR, UV-Vis, magnetic susceptibility measurements, conductivity measurements and FAB-mass spectra. The interaction of the complexes with calf thymus DNA (CT-DNA) has been investigated by UV absorption, viscosity and cyclic voltammetry methods, and the mode of CT-DNA binding to the complexes has been explored. Furthermore, the DNA cleavage activity by the complexes was performed. It was found to be oxidative hydroxyl radical cleavage in the presence of 3-mercaptopropionic acid (MPA). The Schiff base and its complexes have been screened for their antibacterial (Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa) and antifungal (Aspergillus niger, Rhizopus stolonifer, Rhizoctonia bataicola and Candida albicans) activities and the data reveal that the complexes have higher activity than the free ligand. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：135 / 144

页数：10

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