Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

被引：103

作者：

Merle, Benedicte M. J. ^{[1
,6
]}

Colijn, Johanna M. ^{[2
,3
,12
,13
]}

Cougnard-Gregoire, Audrey ^{[1
,6
]}

de Koning-Backus, Alexandra P. M. ^{[2
,3
]}

Delyfer, Marie-Noelle ^{[1
,4
]}

Kiefte-de Jong, Jessica C. ^{[3
]}

Meester-Smoor, Magda ^{[2
,3
,12
,13
]}

Feart, Catherine ^{[1
]}

Verzijden, Timo ^{[2
,3
,12
,13
]}

Samieri, Cecilia ^{[1
]}

Franco, Oscar H. ^{[3
]}

Korobelnik, Jean-Francois ^{[1
,4
]}

Klaver, Caroline C. W. ^{[2
,3
,5
,12
,13
]}

Delcourt, Cecile ^{[1
,6
]}

Ajana, Soufiane ^{[6
]}

Arango-Gonzalez, Blanca ^{[7
]}

Armento, Angela ^{[7
]}

Arndt, Verena ^{[8
]}

Bhatia, Vaibhav ^{[9
]}

Bhattacharya, Shomi S. ^{[9
]}

Biarnes, Marc ^{[10
]}

Borrell, Anna ^{[10
]}

Buhren, Sebastian ^{[11
]}

Calado, Sofia M. ^{[9
]}

Dammeier, Sascha ^{[7
]}

de Jong, Eiko K. ^{[5
]}

De la Cerda, Berta ^{[9
]}

den Hollander, Anneke, I ^{[5
,14
]}

Diaz-Corrales, Francisco J. ^{[9
]}

Diether, Sigrid ^{[7
]}

Emri, Eszter ^{[15
]}

Endermann, Tanja ^{[8
]}

Ferraro, Lucia L. ^{[10
]}

Garcia, Miriam ^{[10
]}

Heesterbeek, Thomas J. ^{[5
]}

Honisch, Sabina ^{[7
]}

Hoyng, Carel B. ^{[5
]}

Kersten, Eveline ^{[5
]}

Kilger, Ellen ^{[7
]}

Langen, Hanno ^{[16
]}

Lengyel, Imre ^{[15
]}

Luthert, Phil ^{[17
]}

Maugeais, Cyrille ^{[16
]}

Mones, Jordi ^{[10
]}

Nogoceke, Everson ^{[16
]}

Peto, Tunde ^{[18
]}

Pool, Frances M. ^{[19
]}

Rodriguez, Eduardo ^{[10
]}

Ueffing, Marius ^{[7
,20
]}

Bartz-Schmidt, Karl U. Ulrich ^{[7
,20
]}

机构：

[1] Univ Bordeaux, Team LEHA, Bordeaux Populat Hlth Res Ctr, INSERM, Bordeaux, France

[2] Erasmus Univ, Med Ctr, Dept Ophthalmol, Rotterdam, Netherlands

[3] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[4] CHU Bordeaux, Serv Ophtalmol, Bordeaux, France

[5] Radhoud Univ, Dept Ophthalmol, Med Ctr, Nijmegen, Netherlands

[6] Univ Bordeaux, Team LEHA, Bordeaux Populat Hlth Res Ctr, INSERM,UMR 1219, Bordeaux, France

[7] Eberhard Karls Univ Tubingen, Ctr Ophthalmol, Inst Ophthalmol Res, Univ Clin Tuebingen, Tubingen, Germany

[8] AYOXXA Biosyst GmbH, Assay Dev, Cologne, Germany

[9] Andalusian Mol Biol & Regenerat Med CABIMER, Dept Regenerat & Cell Therapy, Seville, Spain

[10] Barcelona Mol Fdn, Barcelona, Spain

[11] AYOXXA Biosyst GmbH, Business Dev, Cologne, Germany

[12] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[13] Erasmus MC, Dept Ophthalmol, Rotterdam, Netherlands

[14] Radhoud Univ, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

[15] Queens Univ Belfast, Ctr Expt Med, Belfast, Antrim, North Ireland

[16] F Hoffmann La Roche Ltd, Roche Innovation Ctr Basel, Basel, Switzerland

[17] UCL, Inst Ophthalmol, London, England

[18] Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

[19] UCL Inst Opthalmol, Ocular Biol, London, England

[20] Univ Med Ctr Tubingen, Dept Ophthalmol, Tubingen, Germany

[21] AYOXXA Biosyst GmbH, Res & Dev, Cologne, Germany

来源：

OPHTHALMOLOGY | 2019年 / 126卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

PRIMARY PREVENTION; FISH CONSUMPTION; ASSOCIATION; MACULOPATHY; ADHERENCE; PREVALENCE; ZEAXANTHIN; ROTTERDAM; SURVIVAL; DISEASE;

D O I：

10.1016/j.ophtha.2018.08.006

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced age-related macular degeneration (AMD; the symptomatic form of AMD) in 2 European population-based prospective cohorts. Design: Prospective cohort study of the Rotterdam Study I (RS-I) and the Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (Alienor) Study populations. Participants: Four thousand four hundred forty-six participants 55 years of age or older from the RS-I (The Netherlands) and 550 French adults 73 years of age or older from the Alienor Study with complete ophthalmologic and dietary data were included in the present study. Methods: Examinations were performed approximately every 5 years over a 21-year period (1990-2011) in RS-I and every 2 years over a 4-year period (2006-2012) in the Alienor Study. Adherence to the MeDi was evaluated using a 9-component score based on intake of vegetables, fruits, legumes, cereals, fish, meat, dairy products, alcohol, and the monounsaturated-to-saturated fatty acids ratio. Associations of incidence of AMD with MeDi were estimated using multivariate Cox proportional hazard models. Main Outcomes Measures: Incidence of advanced AMD based on retinal fundus photographs. Results: Among the 4996 included participants, 155 demonstrated advanced incident AMD (117 from the RS- I and 38 from the Alienor Study). The mean follow-up time was 9.9 years (range, 0.6-21.7 years) in the RS-I and 4.1 years (range, 2.5-5.0 years) in the Alienor Study. Pooling data for both the RS- I and Alienor Study, participants with a high (range, 6-9) MeDi score showed a significantly reduced risk for incident advanced AMD compared with participants with a low (range, 0-3) MeDi score in the fully adjusted Cox model (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P = 0.04 for trend). Conclusions: Pooling data from the RS- I and Alienor Study, higher adherence to the MeDi was associated with a 41% reduced risk of incident advanced AMD. These findings support the role of a diet rich in healthful nutrient-rich foods such as fruits, vegetables, legumes, and fish in the prevention of AMD. (C) 2018 by the American Academy of Ophthalmology

引用

页码：381 / 390

页数：10

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