Asnovolins A-G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E

被引：24

作者：

Ishikawa, Kazuki ^{[1
]}

Sato, Fumiaki ^{[1
]}

Itabashi, Takeshi ^{[1
]}

Wachi, Hiroshi ^{[1
]}

Takeda, Hisashi ^{[1
]}

Wakana, Daigo ^{[1
]}

Yaguchi, Takashi ^{[2
]}

Kawai, Ken-ichi ^{[1
]}

Hosoe, Tomoo ^{[1
]}

机构：

[1] Hoshi Univ, Dept Organ Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo, Japan

[2] Chiba Univ, MMRC, Chuo Ku, 1-8-1 Inohama, Chiba, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 09期

基金：

日本学术振兴会;

关键词：

BREAST-CANCER;

D O I：

10.1021/acs.jnatprod.6b00013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven novel spiromeroterpenoids, asnovolins A-G (1-7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A-G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.

引用

页码：2167 / 2174

页数：8