Palladium catalyzed synthesis of sugar-fused indolines via C(sp2)-H/N-H activation

被引：7

作者：

Verma, Ashish Kumar ^{[1
]}

Chennaiah, Ande ^{[1
]}

Dubbu, Sateesh ^{[1
]}

Vankar, Yashwant D. ^{[1
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

CARBOHYDRATE RESEARCH | 2019年 / 473卷

关键词：

C(sp(2))-H/N-H activation in carbohydrates; Annulated sugars; Sugar-fused indolines; Sugar-fused indoles; C-H ACTIVATION; PD(II)-CATALYZED AMINATION; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; MICHAEL ADDITION; C(SP(3))-H BONDS; NATURAL-PRODUCTS; CELL-ADHESION; ISOCHROMANS; ACCESS;

D O I：

10.1016/j.carres.2018.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple Pd(OAc)(2) catalyzed strategy for the synthesis of sugar-fused indolines from 2-N-oxalylamido-2-deoxy-C-aryl glycosides is reported by utilizing N-oxalylamido group as an auxiliary via C(sp(2))-H/N-H Activation. The reaction is successfully applied on glucose as well as galactose derived differently substituted 2-N-oxalylamido-2-deoxy-C-aryl glycosides to give sugar-fused indolines in moderate to good yields. The utility of this strategy in the synthesis of sugar-fused indoles is also described.

引用

页码：57 / 65

页数：9