Autoinflammation and HLA-B27: Beyond Antigen Presentation

被引：13
作者：
Sibley, Cailin H. [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Med, Div Arthrit & Rheumat Dis, 3181 SW Sam Jackson Pk Rd OP 09, Portland, OR 97239 USA
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2016年 / 24卷 / 04期
关键词：
Autoinflammation; HLA-B27; IL-1; innate; spondyloarthritis; UNFOLDED PROTEIN RESPONSE; ACTIVE ANKYLOSING-SPONDYLITIS; ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; GENOME-WIDE ASSOCIATION; TUMOR-NECROSIS-FACTOR; PSORIATIC-ARTHRITIS; TRANSGENIC RATS; INFLAMMATORY DISEASE; REACTIVE ARTHRITIS; DOUBLE-BLIND;
D O I：
10.1080/09273948.2016.1175641
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.
引用
收藏
页码：460 / 469
页数：10
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