Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing

被引：4

作者：

Emmerich, F. ^{[1
]}

Schoenemann, C. ^{[1
]}

Galicki, L. ^{[1
]}

Salama, A. ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Inst Transfus Med, Ctr Tumor Med, D-13353 Berlin, Germany

来源：

TISSUE ANTIGENS | 2008年 / 71卷 / 05期

关键词：

haplotype-specific sequencing; bone marrow transplantation; novel allele;

D O I：

10.1111/j.1399-0039.2008.01030.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have identified a novel HLA-B allele, B*5529. The novel allele differs from HLA-B*5501 by a single nucleotide substitution at codon 479 in exon 3 resulting in an amino acid change from alanine to valine. This alteration neither affects the peptide binding site nor the T-cell receptor (TCR) contact residues. Thus, the newly found allele is estimated to have a low alloreactive potential in case of a mismatch to the most common HLA-B allele B*5501. © 2008 The Authors.

引用

页数：1

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