Nanoscale optical biosensors based on localized surface plasmon resonance spectroscopy

被引：35

作者：

Haes, AJ ^{[1
]}

Van Duyne, RP ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

PLASMONICS: METALLIC NANOSTRUCTURES AND THEIR OPTICAL PROPERTIES | 2003年 / 5221卷

关键词：

plasmon resonance; nanosphere lithography; nanoparticles; biosensors; streptavidin; anti-biotin;

D O I：

10.1117/12.508308

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The Ag nanoparticle based localized surface plasmon resonance (LSPR) nanosensor yields ultrasensitive biodetection with extremely simple, small, light, robust, and low-cost instrumentation. Using LSPR spectroscopy, the model system, biotinylated surface-confined Ag nanotriangles, was used to detect less than one picomolar up to micromolar concentrations of streptavidin. Additionally, the monitoring of anti-biotin binding to biotinylated Ag nanotriangles exhibited that the system could be used as a solution immunoassay. The system was rigorously tested for nonspecific binding interactions and was found to display virtually no adverse results. These results represent important new steps in the development of the LSPR nanobiosensor for applications in medical diagnostics, biomedical research, and environmental science.

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收藏

页码：47 / 58

页数：12

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