Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment

被引：124

作者：

Lin, Xiaoping ^{[1
,2
,3
]}

Xiao, Zizheng ^{[1
,2
]}

Chen, Tao ^{[1
,2
]}

Liang, Steven H. ^{[3
]}

Guo, Huiqin ^{[4
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, Dept Nucl Med, Guangzhou, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Peoples R China

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA 02115 USA

[4] Capital Med Univ, Beijing Sijitan Hosp, Dept Thorac Surg, Beijing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

关键词：

metabolism; tumor; plasticity; glucose; Warburg effect; diagnosis; treatment; EPITHELIAL-MESENCHYMAL TRANSITION; LACTIC-ACID; AEROBIC GLYCOLYSIS; CANCER-CELLS; C-MYC; TRANSCRIPTIONAL REGULATION; THERAPEUTIC TARGETS; B-CELLS; GROWTH; PROGRESSION;

D O I：

10.3389/fonc.2020.00317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant cells support tumor proliferation and progression by adopting to metabolic changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of glucose to lactate, even in the aerobic state and the presence of functioning mitochondria. Glucose metabolism in tumor plasticity has attracted great interests by clinicians and scientists in the past decades. This review discusses the previous and emerging researches on the tumor plasticity altered by changing glucose metabolism in different cancer cells, including cancer stem cells (CSCs). In addition, we summarize the rising applications of glucose metabolism in tumor diagnosis and treatment. Our objective is to direct future investigation on this altered metabolic phenotype and its application in patient care.

引用

页数：10

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