Macrophage dynamics in kidney repair: elucidation of a COX-2-dependent MafB pathway to affect macrophage differentiation

被引：5

作者：

Basile, David P. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Anat Cell Biol & Physiol, 635 Barnhill Dr,MS 2063, Indianapolis, IN 46202 USA

来源：

KIDNEY INTERNATIONAL | 2022年 / 101卷 / 01期

关键词：

D O I：

10.1016/j.kint.2021.10.020

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cylocloxygenase-2 is an important mediator of arachidonic acid metabolism. Pan et al. recently identified a robust increase in the expression of cylocloxygenase-2 in proresolving macrophages (M2) during the repair phase of acute kidney injury. The investigators determined the prostaglandin E2 was produced in macrophages and demonstrated that signaling through the E-type prostanoid receptor 4 stimulated the expression of the anti-inflammatory transcription factor MafB. MafB was further shown to be essential for macrophage differentiation and mediation of the intrinsic repair response following experimental acute kidney injury.

引用

页码：15 / 18

页数：4

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