Universal Infant Hepatitis B Virus (HBV) Vaccination for 35 Years: Moving Toward the Eradication of HBV

被引：30
作者：
Chang, Kai-Chi [1 ,2 ]
Chang, Mei-Hwei [1 ,3 ]
Chen, Huey-Ling [1 ,3 ,4 ]
Wu, Jia-Feng [1 ]
Chang, Chin-Hao [5 ]
Hsu, Hong-Yuan [1 ,4 ]
Ni, Yen-Hsuan [1 ,3 ]
机构：
[1] Natl Taiwan Univ, Coll Med & Hosp, Dept Pediat, Taipei, Taiwan
[2] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan
[3] Natl Taiwan Univ, Coll Med & Hosp, Hepatitis Res Ctr, Taipei, Taiwan
[4] Natl Taiwan Univ, Coll Med & Hosp, Med Educ & Bioeth, Taipei, Taiwan
[5] Natl Taiwan Univ, Coll Med & Hosp, Med Res, Taipei, Taiwan
来源：
JOURNAL OF INFECTIOUS DISEASES | 2022年 / 225卷 / 03期
关键词：
hepatitis B; mother-to-infant transmission; occult HBV infection; vaccination; HEPATOCELLULAR-CARCINOMA; INFECTION; CHILDREN; TRANSMISSION; SEROEPIDEMIOLOGY; IMMUNIZATION; ADOLESCENTS; PROGRAM; TAIWAN;
D O I：
10.1093/infdis/jiab401
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A universal hepatitis B virus (HBV) vaccination program has been implemented in Taiwan since 1984. A total of 1611 individuals in Taipei were enrolled to monitor long-term efficacy. The prevalences of hepatitis B surface antigen (HBsAg) and hepatitis B core antibody in the vaccinated birth cohort were lower than in those born before 1984 (0.4% vs 7.7%, and 2.2% vs 50.8%, respectively; P < .0001). Three vaccine-failure carriers all were born to HBsAg-carrier mothers, probably due to no antiviral intervention during pregnancy. Occult HBV infection was rare in the postvaccination era. High vaccination coverage, comprehensive HBV screening, and antiviral agents for pregnant mothers will be essential to eliminate HBV transmission. Universal hepatitis B virus (HBV) vaccination effectively prevented chronic HBV infection. High vaccination coverage, comprehensive screening, and antiviral agents for pregnant mothers are essential to eliminate its perinatal transmission and for future elimination.
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收藏
页码：431 / 435
页数：5
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