A novel approach to investigate neuronal network activity patterns affected by deep brain stimulation in rats

被引：20

作者：

Klein, Julia ^{[2
]}

Soto-Montenegro, Maria L. ^{[4
,5
]}

Pascau, Javier ^{[4
,5
]}

Guenther, Lydia ^{[1
]}

Kupsch, Andreas ^{[3
]}

Desco, Manuel ^{[6
]}

Winter, Christine ^{[1
,2
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Psychiat & Psychotherapy, Dresden, Germany

[2] Univ Med Berlin, Charite Campus Mitte, Dept Psychiat & Psychotherapy, Berlin, Germany

[3] Univ Med Berlin, Charite Campus Virchow Klinikum, Dept Neurol, Berlin, Germany

[4] Hosp Gen Univ Gregorio Maranon, Unidad Med & Cirugia Expt, Madrid, Spain

[5] CIBERSAM, Madrid, Spain

[6] Univ Carlos III Madrid, Dept Bioengn & Aerosp Engn, Madrid, Spain

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2011年 / 45卷 / 07期

关键词：

Deep brain stimulation; Subthalamic nucleus; FDG-PET; c-Fos-immunostaining; Brain activity patterns; OBSESSIVE-COMPULSIVE DISORDER; HIGH-FREQUENCY STIMULATION; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; EXPRESSION; ACCUMBENS; BEHAVIOR;

D O I：

10.1016/j.jpsychires.2010.12.008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The establishment of new therapeutic indications for deep brain stimulation (DBS) is ambitiously promoted though the underlying mechanisms remain contested. Here, we report that PET-imaging and subsequent c-Fos-immunostaining in rats constitute a new translational approach to further understand DBS-mechanisms and -effectiveness. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：927 / 930

页数：4

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